Cytotoxicity of Isoflavones from Millettia Dura

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Cytotoxicity of isoflavones from Millettia dura.pdf (696.24 KB)
Date
2021
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Natural Product Research
Abstract
The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM).
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Keywords
Millettia dura; Leguminosae; isoflavone; cytotoxicity
Citation
Buyinza, D., Yang, L. J., Derese, S., Ndakala, A., Coghi, P., Heydenreich, M., ... & Yenesew, A. (2021). Cytotoxicity of isoflavones from Millettia dura. Natural Product Research, 35(16), 2744-2747.https://doi.org/10.1080/14786419.2019.1660335
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https://nru.uncst.go.ug/handle/123456789/7274
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Agricultural and Veterinary Sciences