Inhaled Nitric Oxide and Cerebral Malaria: Basis of a Strategy for Buying Time for Pharmacotherapy

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dc.contributor.authorBergmark, Brian
dc.contributor.authorBergmark, Regan
dc.contributor.authorBeaudrap, Pierre De
dc.contributor.authorBoum, Yap
dc.contributor.authorMwanga-Amumpaire, Juliet
dc.contributor.authorCarroll, Ryan
dc.contributor.authorZapol, Warren
dc.date.accessioned2022-05-01T23:34:23Z
dc.date.available2022-05-01T23:34:23Z
dc.date.issued2012
dc.description.abstractThere are approximately 225–600 million new malaria infections worldwide annually, with severe and cerebral malaria representing major causes of death internationally. The role of nitric oxide (NO) in the host response in cerebral malaria continues to be elucidated, with numerous known functions relating to the cytokine, endovascular and cellular responses to infection with Plasmodium falciparum. Evidence from diverse modes of inquiry suggests NO to be critical in modulating the immune response and promoting survival in patients with cerebral malaria. This line of investigation has culminated in the approval of 2 phase II randomized prospective clinical trials in Uganda studying the use of inhaled NO as adjuvant therapy in children with severe malaria. The strategy underlying both trials is to use the sytemic antiinflammatory properties of inhaled NO to “buy time” for chemical antiparasite therapy to lower the parasite load. This article reviews the nexus of malaria and NO biology with a primary focus on cerebral malaria in humans.en_US
dc.identifier.citationBergmark, B., Bergmark, R., De Beaudrap, P., Boum, Y., Mwanga-Amumpaire, J., Carroll, R., & Zapol, W. (2012). Inhaled nitric oxide and cerebral malaria: basis of a strategy for buying time for pharmacotherapy. The Pediatric Infectious Disease Journal, 31(12), e250-e254. DOI: 10.1097/INF.0b013e318266c113en_US
dc.identifier.issn0891-3668/12/3112-e250
dc.identifier.other10.1097/INF.0b013e318266c113
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3124
dc.language.isoenen_US
dc.publisherThe Pediatric Infectious Disease Journalen_US
dc.subjectInhaled nitric oxideen_US
dc.subjectCerebral malariaen_US
dc.subjectNitric oxide synthaseen_US
dc.subjectPlasmodium falciparumen_US
dc.titleInhaled Nitric Oxide and Cerebral Malaria: Basis of a Strategy for Buying Time for Pharmacotherapyen_US
dc.typeArticleen_US
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