The Alteration of Lipid Metabolism in Burkitt Lymphoma Identifies a Novel Marker: Adipophilin

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dc.contributor.authorAmbrosio, Maria R.
dc.contributor.authorPiccaluga, Pier P.
dc.contributor.authorPonzoni, Maurilio
dc.contributor.authorRocca, Bruno J.
dc.contributor.authorMalagnino, Valeria
dc.contributor.authorOnorati, Monica
dc.contributor.authorFalco, Giulia De
dc.contributor.authorCalbi, Valeria
dc.contributor.authorOgwang, Martin
dc.contributor.authorNaresh, Kikkeri N.
dc.contributor.authorPileri, Stefano A.
dc.contributor.authorDoglioni, Claudio
dc.contributor.authorLeoncini, Lorenzo
dc.contributor.authorLazzi, Stefano
dc.date.accessioned2022-04-29T15:26:17Z
dc.date.available2022-04-29T15:26:17Z
dc.date.issued2012
dc.description.abstractRecent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this is reflected by the presence of lipid droplets which are visible in the cytoplasm of neoplastic cells in cytological preparations. These vacuoles are not identifiable in biopsy section as lipids are ‘‘lost’’ during tissue processing. Methods and Results: In this study we investigated the expression of genes involved in lipid metabolism, at both RNA and protein level in Burkitt lymphoma and in other B-cell aggressive lymphoma cases. Gene expression profile indicated a significant over-expression of the adipophilin gene and marked up-regulation of other genes involved in lipid metabolism in Burkitt lymphoma. These findings were confirmed by immunohistochemistry on a series od additional histological samples: 45 out of 47 BL cases showed strong adipophilin expression, while only 3 cases of the 33 of the not-Burkitt lymphoma category showed weak adipophilin expression (p,0.05). Conclusions: Our preliminary results suggest that lipid metabolism is altered in BL, and this leads to the accumulation of lipid vacuoles. These vacuoles may be specifically recognized by a monoclonal antibody against adipophilin, which may therefore be a useful marker for Burkitt lymphoma because of its peculiar expression pattern. Moreover this peptide might represent an interesting candidate for interventional strategies.en_US
dc.identifier.citationAmbrosio MR, Piccaluga PP, Ponzoni M, Rocca BJ, Malagnino V, et al. (2012) The Alteration of Lipid Metabolism in Burkitt Lymphoma Identifies a Novel Marker: Adipophilin. PLoS ONE 7(8): e44315. doi:10.1371/journal.pone.0044315en_US
dc.identifier.other10.1371/journal.pone.0044315
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2994
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectLipid Metabolismen_US
dc.subjectBurkitt Lymphomaen_US
dc.subjectNovel Markeren_US
dc.subjectAdipophilinen_US
dc.titleThe Alteration of Lipid Metabolism in Burkitt Lymphoma Identifies a Novel Marker: Adipophilinen_US
dc.typeArticleen_US
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