Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda

Simple item page
dc.contributor.authorStein, Catherine M.
dc.contributor.authorZalwango, Sarah
dc.contributor.authorMalone, LaShaunda L.
dc.contributor.authorThiel, Bonnie
dc.contributor.authorMupere, Ezekiel
dc.contributor.authorNsereko, Mary
dc.contributor.authorOkware, Brenda
dc.contributor.authorKisingo, Hussein
dc.contributor.authorLancioni, Christina L.
dc.contributor.authorBark, Charles M.
dc.contributor.authorWhalen, Christopher C.
dc.contributor.authorJoloba, Moses L.
dc.contributor.authorBoom, W. Henry
dc.contributor.authorMayanja-Kizza, Harriet
dc.date.accessioned2021-12-10T16:51:39Z
dc.date.available2021-12-10T16:51:39Z
dc.date.issued2017
dc.description.abstractTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major public health problem. Household contact studies identify children and adults along the spectrum from Mtb exposure to disease. In the Kawempe Community Health Study (conducted in Kampala, Uganda), 872 culture-confirmed pulmonary TB cases and their 2,585 contacts were enrolled during 2002–2012 and followed for up to 2 years each. Risk factors identified by time-to-event analysis for secondary TB differed among children, women, and men. Younger age (P = 0.0061), human immunodeficiency virus (HIV) (P = 0.0002), thinness (P = 0.01), absent bacille Calmette-Guérin vaccination (P = 0.002), and epidemiologic risk score (P < 0.0001) were risks for children. For women, risks were HIV (P < 0.0001), thinness (World Health Organization criteria; P < 0.0001), and epidemiologic risk score (P = 0.003). For men, HIV (P = 0.0007) and low body mass index (P = 0.008) resulted in faster progression to TB. Tuberculin skin testing (TST) identified contacts with Mtb infection and those with persistently negative TST. Risks for faster time to Mtb infection were identified, and included age (P = 0.0007), baseline TST induration (P < 0.0001), and epidemiologic risk score (P < 0.0001) only in children. Those with persistently negative TST comprised 10% of contacts but had no unique epidemiologic characteristics among adults. The burden of Mtb infection and disease is high in TB households, and risk factors for progression from exposure to infection and disease differ among children, women, and men.en_US
dc.identifier.citationStein, C. M., Zalwango, S., Malone, L. L., Thiel, B., Mupere, E., Nsereko, M., ... & Mayanja-Kizza, H. (2018). Resistance and susceptibility to Mycobacterium tuberculosis infection and disease in tuberculosis households in Kampala, Uganda. American journal of epidemiology, 187(7), 1477-1489. DOI: 10.1093/aje/kwx380en_US
dc.identifier.other10.1093/aje/kwx380
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/263
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectInfectionen_US
dc.subjectDiseaseen_US
dc.subjectHouseholdsen_US
dc.titleResistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Resistance and Susceptibility to Mycobacterium tuberculosis Infection.pdf
Size:
438.27 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences