A retrospective analysis of antimicrobial resistance in pathogenic Escherichia coli and Salmonella spp. isolates from poultry in Uganda

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dc.contributor.authorKakooza, Steven
dc.contributor.authorMuwonge, Adrian
dc.contributor.authorNabatta, Esther
dc.contributor.authorEneku, Wilfred
dc.contributor.authorDickson, Dickson
dc.contributor.authorWampande, Eddie
dc.contributor.authorMunyiirwa, Damian
dc.contributor.authorKayaga, Edrine
dc.contributor.authorTumwebaze, Maria Agnes
dc.contributor.authorAfayoa, Mathias
dc.contributor.authorSsajjakambwe, Paul
dc.contributor.authorTayebwa, Dickson Stuart
dc.contributor.authorSayaka, Tsuchida
dc.contributor.authorOkubo, Torahiko
dc.contributor.authorKazunari, Ushida
dc.contributor.authorSakurai, Ken’ichi
dc.contributor.authorMutebi, Francis
dc.date.accessioned2025-02-02T10:55:13Z
dc.date.available2025-02-02T10:55:13Z
dc.date.issued2021-05
dc.description.abstractThere are increasing reports of antimicrobial treatment failures for bacterial diseases of poultry in Uganda. The paucity of data on antimicrobial resistance (AMR) of pathogenic bacteria in Uganda is a major setback to AMR control. This study investigated the occurrence of fowl typhoid, colibacillosis, and AMR in associated pathogens from 2012 to 2018. Laboratory records from the Central Diagnostic Laboratory (CDL), a National Veterinary Diagnostic Facility located at Makerere University, were reviewed. Archived isolates of the causative bacteria for the two diseases were also evaluated for AMR. The frequencies of the two disease conditions, their clinical and necropsy presentations and the demographic data of the diagnostic samples were summarized from the records. Archived bacterial isolates were revived before antimicrobial susceptibility testing. This was done on Mueller Hinton agar using the disk diffusion method, against 16 antimicrobials of medical and veterinary importance according to the Clinical Laboratory Standards Institute guidelines. A total of 697 poultry cases were presented for bacteriological investigations in the review period. Colibacillosis and salmonellosis had prevalence rates of 39.7% (277/697) and 16.2% (113/697), respectively. A total of 63 and 92 isolates of Escherichia coli and Salmonella spp., respectively, were archived but 43 (68.3%) E. coli and 47 (51.1%) Salmonella spp. isolates were recovered and evaluated for AMR. Multidrug resistance was more frequent in E. coli (38; 88.4%) than salmonellae (25; 53.2%), (p < 0.001). The high prevalence of colibacillosis, salmonellosis and the AMR of associated pathogens warrants immediate institution of appropriate disease control measures.
dc.identifier.citationSteven Kakooza, Adrian Muwonge, Esther Nabatta, Wilfred Eneku, Dickson Ndoboli, Eddie Wampande, Damian Munyiirwa, Edrine Kayaga, Maria Agnes Tumwebaze, Mathias Afayoa, Paul Ssajjakambwe, Dickson Stuart Tayebwa, Sayaka Tsuchida, Torahiko Okubo, Kazunari Ushida, Ken’ichi Sakurai & Francis Mutebi (2021) A retrospective analysis of antimicrobial resistance in pathogenic Escherichia coli and Salmonella spp. isolates from poultry in Uganda, International Journal of Veterinary Science and Medicine, 9:1, 11-21, DOI: 10.1080/23144599.2021.1926056
dc.identifier.urihttps://doi.org/10.1080/23144599.2021.1926056
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9907
dc.language.isoen
dc.publisherInternational Journal of Veterinary Science and Medicine
dc.titleA retrospective analysis of antimicrobial resistance in pathogenic Escherichia coli and Salmonella spp. isolates from poultry in Uganda
dc.typeArticle
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