Detection of K103N in Ugandan women after repeated exposure to single dose Nevirapine

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dc.contributor.authorFlysa, Tamara S.
dc.contributor.authorMwathab, Anthony
dc.contributor.authorGuay, Laura A.
dc.contributor.authorNakabiitoc, Clemensia
dc.contributor.authorDonnell, Deborah
dc.contributor.authorMusoke, Philippa
dc.contributor.authorMmirod, Francis
dc.contributor.authorJacksona, J. Brooks
dc.contributor.authorEshleman, Susan H.
dc.date.accessioned2021-12-15T13:12:55Z
dc.date.available2021-12-15T13:12:55Z
dc.date.issued2007
dc.description.abstractObjectives: Use of single dose nevirapine (SD NVP) for prevention of HIV-1 mother-tochild transmission (pMTCT) is associated with selection of K103N-containing HIV variants. Repeat use of SD NVP for pMTCT may influence emergence and persistence of NVP-resistant variants. Design: K103N-containing variants were studied in 48 Ugandan women who received SD NVP in the HIVNET 012 trial, and were re-exposed to SD NVP in one (n¼44) or two (n¼4) subsequent pregnancies during a 5-year follow-up study. Methods: Samples were analyzed using the LigAmp assay (assay cutoff: 0.5% K103N). Results: Among 44 women who were re-exposed to SD NVP in one subsequent pregnancy, 37.8% had K103N detected within 1 year of SD-NVP re-exposure. Detection of K103N was independently associated with detection of K103N 6–8 weeks after the first SD NVP exposure and with pre-NVP viral load. The portion of women with undetectable K103N by 2 years after SD NVP administration was similar after first versus second use of SD NVP for pMTCT. K103N was undetectable in 93.2% of evaluable women by 3 years of re-exposure. Only two of four women who received SD NVP in two pregnancies during the follow-up study had K103N detected after the last SD NVP exposure. Conclusions: K103N was detected in some women within 1 year of SD NVP reexposure, but faded from detection in most women by 3 years after re-exposure. Detection of K103N by 1 year after SD NVP re-exposure was associated with prior selection of K103N-containing variants and with pre-NVP viral load.en_US
dc.identifier.citationFlys, T. S., Mwatha, A., Guay, L. A., Nakabiito, C., Donnell, D., Musoke, P., ... & Eshleman, S. H. (2007). Detection of K103N in Ugandan women after repeated exposure to single dose nevirapine. Aids, 21(15), 2077-2082.doi: 10.1097/QAD.0b013e3282703847en_US
dc.identifier.issn0269-9370
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/622
dc.language.isoenen_US
dc.publisherJournal of virologyen_US
dc.subjectAfricaen_US
dc.subjectHIV drug resistanceen_US
dc.subjectNevirapineen_US
dc.subjectWomenen_US
dc.titleDetection of K103N in Ugandan women after repeated exposure to single dose Nevirapineen_US
dc.typeArticleen_US
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