Intraluminally injected oil induces changes in vascular permeability in the 'sensitized' and 'non-sensitized' uterus of the mouse

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dc.contributor.authorMilligan, S. R.
dc.contributor.authorMirembe, Florence M.
dc.date.accessioned2022-01-21T20:22:59Z
dc.date.available2022-01-21T20:22:59Z
dc.date.issued1985
dc.description.abstractAfter suitable sensitization of ovariectomized mice with progesterone and oestradiol, the intrauterine instillation of oil produces a massive decidual cell reaction. Vascular permeability, as reflected by the extra-vascular accumulation of 125I-labelled human serum albumin, increased after oil instillation and was maintained at 2\p=n-\3times control values for at least the next 3 days. Although oil instillation did not produce a decidual response in females treated with progesterone alone, an increase in vascular permeability (about 2 times control levels) still occurred. This response peaked 8 h after oil instillation and was not maintained. These results indicate that the progesterone\x=req-\dominated uterus which has not been sensitized with oestradiol cannot be viewed as completely unresponsive to the stimulus of oil and demonstrate that a marked increase in vascular permeability is not itself sufficient to induce decidualization of progesterone-dominated uterine stromal cells. The uterine extravascular accumulation of 125I-labelled albumin was increased both in association with tribromoethanol anaesthesia and after oestradiol treatment of progesterone-primed animals. In pregnant mice, the appearance of Pontamine Sky Blue spots provided an earlier indication of implantation than did determination of total uterine extravascular 125I\x=req-\ labelled albumin accumulation.en_US
dc.identifier.citationMilligan, S. R., & Mirembe, F. M. (1985). Intraluminally injected oil induces changes in vascular permeability in the 'sensitized' and 'non-sensitized' uterus of the mouse. Reproduction, 74(1), 95-104.en_US
dc.identifier.urihttps://rep.bioscientifica.com/view/journals/rep/74/1/jrf_74_1_012.xml
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1402
dc.language.isoenen_US
dc.publisherReproductionen_US
dc.subjectInjected oilen_US
dc.subjectVascular permeabilityen_US
dc.subjectUterus of the mouseen_US
dc.titleIntraluminally injected oil induces changes in vascular permeability in the 'sensitized' and 'non-sensitized' uterus of the mouseen_US
dc.typeArticleen_US
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