Trends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing across low-income and middle-income countries in 2005–17: a systematic analysis of 132 national surveys from 73 countries

Simple item page
dc.contributor.authorAllwell-Brown, Gbemisola
dc.contributor.authorHussain-Alkhateeb, Laith
dc.contributor.authorKitutu, Freddy Eric
dc.contributor.authorStrömdahl, Susanne
dc.contributor.authorMårtensson, Andreas
dc.contributor.authorJohanssonAllwell-Brown, Emily White
dc.date.accessioned2022-02-05T09:07:00Z
dc.date.available2022-02-05T09:07:00Z
dc.date.issued2020
dc.description.abstractGlobal assessments of antibiotic consumption have relied on pharmaceutical sales data that do not measure individual-level use, and are often unreliable or unavailable for low-income and middle-income countries (LMICs). To help fill this evidence gap, we compiled data from national surveys in LMICs in 2005–17 reporting antibiotic use for sick children under the age of 5 years. Methods Based on 132 Demographic and Health Surveys and Multiple Indicator Cluster Surveys from 73 LMICs, we analysed trends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing by WHO region, World Bank income classification, and symptom complaint. A logit transformation was used to estimate the outcome using a linear Bayesian regression model. The model included country-level socioeconomic, disease incidence, and health system covariates to generate estimates for country-years with missing values. Findings Across LMICs, reported antibiotic use among sick children under 5 years of age increased from 36·8% (uncertainty interval [UI] 28·8–44·7) in 2005 to 43·1% (33·2–50·5) in 2017. Low-income countries had the greatest relative increase; in these countries, reported antibiotic use for sick children under 5 years of age rose 34% during the study period, from 29·6% (21·2–41·1) in 2005 to 39·5% (32·9–47·6) in 2017, although it remained the lowest of any income group throughout the study period. Interpretation We found a limited but steady increase in reported antibiotic use for sick children under 5 years of age across LMICs in 2005–17, although overlapping UIs complicate interpretation. The increase was largely driven by gains in low-income countries. Our study expands the evidence base from LMICs, where strengthening antibiotic consumption and resistance surveillance is a global health priority.en_US
dc.identifier.citationAllwell-Brown, G., Hussain-Alkhateeb, L., Kitutu, F. E., Strömdahl, S., Mårtensson, A., & Johansson, E. W. (2020). Trends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing across low-income and middle-income countries in 2005–17: a systematic analysis of 132 national surveys from 73 countries. The Lancet Global Health, 8(6), e799-e807.en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2214109X20300796
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1930
dc.language.isoenen_US
dc.publisherThe Lancet Global Healthen_US
dc.subjectAntibiotic useen_US
dc.subjectFeveren_US
dc.subjectDiarrhoeaen_US
dc.subjectCoughen_US
dc.subjectLow-income and middle-income countriesen_US
dc.subjectNational surveysen_US
dc.titleTrends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing across low-income and middle-income countries in 2005–17: a systematic analysis of 132 national surveys from 73 countriesen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Trends in reported antibiotic use among children under.pdf
Size:
819.57 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences