Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors

Simple item page
dc.contributor.authorSobarzo, Ariel
dc.contributor.authorHerbert, Andrew S.
dc.contributor.authorOchayon, David E.
dc.contributor.authorEskira, Yael
dc.contributor.authorEgesa, Moses
dc.contributor.authorCose, Stephen
dc.contributor.authorLutwama, Julius Julian
dc.contributor.authorDye, John M.
dc.contributor.authorLobel, Leslie
dc.date.accessioned2023-06-22T19:13:25Z
dc.date.available2023-06-22T19:13:25Z
dc.date.issued2016
dc.description.abstractRobust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood. To address this, we examined residual immune responses in survivors of the Sudan virus (SUDV) outbreak in Gulu, Uganda (2000–2001). Cytokine and chemokine expression levels in SUDV stimulated whole blood cultures were assessed by multiplex ELISA and flow cytometry. Antibody and corresponding neutralization titers were also determined. Flow cytometry and multiplex ELISA results demonstrated significantly higher levels of cytokine and chemokine responses in survivors with serological neutralizing activity. This correspondence was not detected in survivors with serum reactivity to SUDV but without neutralization activity. This previously undefined relationship between memory CD4 T cell responses and serological neutralizing capacity in SUDV survivors is key for understanding long lasting immunity in survivors of filovirus infections.en_US
dc.identifier.citationSobarzo, A., Stonier, S. W., Herbert, A. S., Ochayon, D. E., Kuehne, A. I., Eskira, Y., ... & Lobel, L. (2016). Correspondence of neutralizing humoral immunity and CD4 T cell responses in long recovered Sudan virus survivors. Viruses, 8(5), 133.en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8974
dc.language.isoenen_US
dc.publisherVirusesen_US
dc.subjectCellular immunityen_US
dc.subjectEbola survivorsen_US
dc.subjectNeutralizing antibodiesen_US
dc.subjectMemory immunityen_US
dc.titleCorrespondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivorsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors.pdf
Size:
1.47 MB
Format:
Adobe Portable Document Format
Description:
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences