A Supraclavicular ALK-Positive Anaplastic Large-Cell Lymphoma Initially Misdiagnosed and Yet Successfully Treated with Wide Excision and Adjuvant Chemotherapy: a Case Report

Simple item page
dc.contributor.authorLekuya, Hervé Monka
dc.contributor.authorWamala Kalanzi, Edris
dc.contributor.authorMbiine, Ronald
dc.contributor.authorOmoding, Abraham
dc.contributor.authorRosenwald, Andreas
dc.contributor.authorLemperle, Gottfried
dc.contributor.authorBringmann, Gerhard
dc.date.accessioned2023-09-04T14:13:06Z
dc.date.available2023-09-04T14:13:06Z
dc.date.issued2019
dc.description.abstractALK-positive Anaplastic Large-Cell Lymphomas (ALCL) are chemo-sensitive cancers; combination of histologic and immunophenotypic or genetic studies remains the main strategy to prevent their unnecessary surgical excision as they canmimic softtissues sarcomas in histology. In sub-Saharan Africa, however, availability and affordability of immunophenotypic studies, especially extended immunohistochemistry (IHC) tests, constitute major limitations for accurate diagnoses. The case presented herein is an example of a heavy surgical management resulting from an initially inaccurate diagnosis, but eventually treated successfully. Case presentation A 15-year-old female patient presented with a 5-month history of a painless right supraclavicular mass. The initial biopsies had conflicting histology reports. In view of its rapid growth, it was first managed surgically, as a high-grade sarcoma stage T4N1M0: a wide “en bloc resection” with primary flap covering was done. Post-operative histology with an extended IHC from the widely resected tissue finally revealed an ALK-positive ALCL, which proved to be sensitive to chemotherapy. An adjuvant chemotherapy of six cycles of CHOP regimen followed with a good response; the patient became clinically stable, and all the investigations that were done, including a PET-CT scan, could not detect any residual active disease. She was still disease-free at 2 years after completion of chemotherapy. Conclusions Although cost-effective, combined histologic and immunophenotypic studies, especially extended IHC tests, can reduce the incidence of misdiagnosed large-cell lymphoma. As exemplified in this present case, obtaining appropriate and sufficient tissue from the tumor could possibly increase the chance of finding an accurate diagnosis.en_US
dc.identifier.citationLekuya, H. M., Kalanzi, E. W., Mbiine, R., Omoding, A., Rosenwald, A., Lemperle, G., & Bringmann, G. (2019). A supraclavicular ALK-positive anaplastic large-cell lymphoma initially misdiagnosed and yet successfully treated with wide excision and adjuvant chemotherapy: A case report. SN Comprehensive Clinical Medicine, 1, 716-725. https://doi.org/10.1007/s42399-019-00112-2https://doi.org/10.1007/s42399-019-00112-2en_US
dc.identifier.urihttps://doi.org/10.1007/s42399-019-00112-2
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9165
dc.language.isoenen_US
dc.publisherSN Comprehensive Clinical Medicineen_US
dc.subjectAnaplastic large-cell lymphomaen_US
dc.subjectCase reporten_US
dc.subjectChemotherapyen_US
dc.subjectFascio-cutaneous flapen_US
dc.subjectIHCen_US
dc.subjectPET-CT scanen_US
dc.subjectMisdiagnosisen_US
dc.titleA Supraclavicular ALK-Positive Anaplastic Large-Cell Lymphoma Initially Misdiagnosed and Yet Successfully Treated with Wide Excision and Adjuvant Chemotherapy: a Case Reporten_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
A Supraclavicular ALK-Positive Anaplastic Large-Cell Lymphoma.pdf
Size:
2.31 MB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences