Randomized Phase IIA Trial of Gemcitabine Compared With Bleomycin Plus Vincristine for Treatment of Kaposi’s Sarcoma in Patients on Combination Antiretroviral Therapy in Western Kenya

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dc.contributor.authorBusakhala, Naftali W.
dc.contributor.authorWaako, Paul J.
dc.contributor.authorStrother, Matthew R.
dc.contributor.authorKipyegon Keter, Alfred
dc.contributor.authorKimutai Kigen, Gabriel
dc.contributor.authorChite Asirwa, Fredrick
dc.contributor.authorLoehrer, Patrick J.
dc.date.accessioned2021-12-12T11:44:39Z
dc.date.available2021-12-12T11:44:39Z
dc.date.issued2018
dc.description.abstractKaposi’s sarcoma (KS) is a spindle cell tumor resulting from growth dysregulation in the setting of infection with human herpes virus-8 (also called KS herpes virus). Advanced KS is characterized by poor responses to antiretroviral therapy and some of the chemotherapy readily accessible to patients in low-resource areas. Gemcitabine induced partial and complete regression of AIDS-associated KS (AIDS-KS) in 11 of 24 patients in a pilot study. The current study compares the antimetabolite gemcitabine with the standard care bleomycin and vincristine (BV) in the treatment of chemotherapy-naïve patients with AIDS-KS in a resource-limited setting.en_US
dc.identifier.citationBusakhala, N. W., Waako, P. J., Strother, M. R., Keter, A. K., Kigen, G. K., Asirwa, F. C., & Loehrer, P. J. (2018). Randomized phase IIA trial of gemcitabine compared with bleomycin plus vincristine for treatment of Kaposi’s sarcoma in patients on combination antiretroviral therapy in Western Kenya. Journal of global oncology, 4, 1-9.DOI: https://doi.org/10.1200/JGO.17.00077en_US
dc.identifier.uriDOI: https://doi.org/10.1200/JGO.17.00077
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/340
dc.language.isoenen_US
dc.publisherJournal of global oncologyen_US
dc.subjectBleomycinen_US
dc.subjectTreatment of Kaposi’sen_US
dc.subjectAntiretroviralen_US
dc.subjectPhase IIA Trialen_US
dc.titleRandomized Phase IIA Trial of Gemcitabine Compared With Bleomycin Plus Vincristine for Treatment of Kaposi’s Sarcoma in Patients on Combination Antiretroviral Therapy in Western Kenyaen_US
dc.typeTechnical Reporten_US
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