Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial

dc.contributor.authorMaitland, Kathryn
dc.contributor.authorKiguli,Sarah
dc.contributor.authorOlupot-Olupot, Peter
dc.contributor.authorAkech, Samuel O.
dc.contributor.authorOpoka, Robert O.
dc.contributor.authorNyeko, Richard
dc.contributor.authorNteziyaremye, Julius
dc.date.accessioned2025-02-26T08:22:39Z
dc.date.available2025-02-26T08:22:39Z
dc.date.issued2013-03-14
dc.description.abstractEarly rapid fluid resuscitation (boluses) in African children with severe febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus). We explored the effect of boluses on 48-hour all-cause mortality byclinical presentation at enrolment, hemodynamic changes over the first hour, andon different modes of death, according to terminal clinical events. We hypothesizethat boluses may cause excess deaths from neurological or respiratory eventsrelating to fluid overload.
dc.identifier.citationMaitland, K., George, E. C., Evans, J. A., Kiguli, S., Olupot-Olupot, P., Akech, S. O., ... & FEAST trial group null@ null. com. (2013). Exploring mechanisms of excess mortality with early fluid resuscitation: insightsfrom the FEAST trial. BMC medicine, 11, 1-15. https://doi.org/10.1186/1741-7015-11-68
dc.identifier.otherhttps://doi.org/10.1186/1741-7015-11-68
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10007
dc.language.isoen
dc.publisherBMC medicine
dc.titleExploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
dc.typeArticle
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