Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

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dc.contributor.authorKajumbula, Henry
dc.contributor.authorByarugaba, Wilson
dc.contributor.authorWayengera, Misaki
dc.date.accessioned2021-12-13T13:14:17Z
dc.date.available2021-12-13T13:14:17Z
dc.date.issued2012
dc.description.abstractMalaria causes immense human morbidity and mortality globally. The plasmodium species vivax and falciparum cause over 75 % clinical malaria cases. Until now, gene-based strategies against malaria have only been applied to plasmodium species and their mosquito-vector. Merozoites of these two respective plasmodium species target and invade red blood cells (RBCs) by using the duffy antigen receptor for chemokines (DARC), and Sialic Acid (SLC4A1) residues of the O-linked glycans of Glycophorin A. RBCs of naturally selected duffy-negative blacks are resistant to P.vivax tropism. We hypothesized that artificial aberration of the host-pathway by target mutagenesis of either RBC –receptors, may abolish or reduce susceptibility of the host to malaria. As a first step towards the experimental actualization of these concepts, we aimed to identify zinc finger arrays (ZFAs) for constructing ZFNs that target genes of either wild-type host-RBC- receptors.en_US
dc.identifier.citationKajumbula et al.: Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria. Genetic Vaccines and Therapy 2012 10:8. doi:10.1186/1479-0556-10-8en_US
dc.identifier.other10.1186/1479-0556-10-8
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/441
dc.language.isoenen_US
dc.publisherGenetic Vaccines and Therapyen_US
dc.subjectMalariaen_US
dc.subjectPlasmodiumen_US
dc.subjectP. falciparumen_US
dc.subjectP. vivaxen_US
dc.subjectMerozoitesen_US
dc.subjectRBC-receptorsen_US
dc.subjectDarcen_US
dc.subjectGlycophorin Aen_US
dc.subjectZinc finger nucleasesen_US
dc.subjectHost-pathwayen_US
dc.subjectAbrogationen_US
dc.subjectGenetic vaccineen_US
dc.titleTargeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malariaen_US
dc.typeArticleen_US
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