Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey

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dc.contributor.authorBwogi, Josephine
dc.contributor.authorBraka, Fiona
dc.contributor.authorMakumbi, Issa
dc.contributor.authorMishra, Vinod
dc.contributor.authorBakamutumaho, Barnabas
dc.contributor.authorNanyunja, Miriam
dc.contributor.authorOpio, Alex
dc.contributor.authorDowning, Robert
dc.contributor.authorBiryahwaho, Benon
dc.contributor.authorLewis, Rosamund F.
dc.date.accessioned2022-01-20T10:21:37Z
dc.date.available2022-01-20T10:21:37Z
dc.date.issued2009
dc.description.abstractInfant immunization against hepatitis B began in Uganda in 2002. Objective: To determine the baseline prevalence of hepatitis B virus (HBV) infection and explore risk factors. Methods: A hepatitis B prevalence study was nested in the 2005 national HIV/AIDS serobehavioural survey. Demographic characteristics and risk factors were explored by questionnaire. One third of blood specimens (n=5875) from adults aged 15 to 59 years were tested for hepatitis B core antibodies (HBcAb); positive specimens were tested for hepatitis B surface antigen (HBsAg). Results: HBcAb was present in 52.3% (95% CI: 51.0-53.6) of adults, and HBsAg in 10.3% (9.5-11.1). By 15-19 years of age, 40.0% had been infected with HBV. Prevalence of both markers was significantly higher across northern Uganda, in rural areas, among the poor and least educated, and in uncircumcised men. Other independent predictors of infection were age, ethnic group, occupation, number of sex partners, and HIV and HSV-2 status. Conclusion: Hepatitis B virus infection is highly endemic in Uganda, with transmission occurring in childhood and adulthood. More than 1.4 million adults are chronically infected and some communities disproportionately affected. The hepatitis B infant immunization programme should be sustained and catch-up vaccination considered for older children.en_US
dc.identifier.citationBwogi, J., Braka, F., Makumbi, I., Mishra, V., Bakamutumaho, B., Nanyunja, M., ... & Lewis, R. F. (2009). Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey. African health sciences, 9(2).en_US
dc.identifier.otherhttps://www.ajol.info/index.php/ahs/article/view/43770
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1342
dc.language.isoenen_US
dc.publisherAfrican health sciencesen_US
dc.subjectHepatitis B infectionen_US
dc.subjectUgandaen_US
dc.subjectNational serosurveyen_US
dc.titleHepatitis B infection is highly endemic in Uganda: findings from a national serosurveyen_US
dc.typeArticleen_US
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