Acute and Sub-acute Toxicity Evaluation in Rats of PPOJ5 and ADOJ6 Herbal Remedies Used Traditionally in the Management of HIV Infection

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dc.contributor.authorJoseph, Oloro
dc.contributor.authorMukasa, Kiguli James
dc.contributor.authorRitah, Nabirumbi
dc.contributor.authorKihdze, Tanayen Julius
dc.contributor.authorImanirampa, Lawrence
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorGanafa, Amon Agaba
dc.date.accessioned2021-12-16T06:40:52Z
dc.date.available2021-12-16T06:40:52Z
dc.date.issued2016
dc.description.abstractThe use of herbal medicine in the treatment of many ailments is on the rise. It’s a common practice in many rural communities where access to health care is poor but also in the developed world. There is however, no much attention paid to the potential toxicity of these herbal products. This study was conducted to determine the toxicity of two herbal remedies; PPOJ5 and ADOJ6, being used for the management of patients with HIV. Both acute and sub-acute toxicity were evaluated using a rat model. Liver, renal and haematological parameters were measured. PPOJ5 was found slightly toxic with an estimated LD50 of 1.341 g/kg body weight and it significantly elevated lymphocyte count. ADOJ6 was safe in both acute and sub-acute toxicity studies. There is a need to evaluate the extracts of both PPOJ5 and ADOJ6 on isolated human Peripheral Blood Mononuclear Cells (PBMCs) to determine their safety level and possible immunostimulatory effects of PPOJ5.en_US
dc.identifier.citationJoseph, O., Mukasa, K. J., Ritah, N., Kihdze, T. J., Imanirampa, L., Bajunirwe, F., & Ganafa, A. A. (2016). Acute and Sub-acute Toxicity Evaluation in Rats of PPOJ5 and ADOJ6 Herbal Remedies Used Traditionally in the Management of HIV Infection. European Journal of Medicinal Plants, 1-6.DOI: 10.9734/EJMP/2016/28358en_US
dc.identifier.issn2231-0894
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/688
dc.language.isoenen_US
dc.publisherJournal of Medicinal Plantsen_US
dc.subjectAcuteen_US
dc.subjectSub-acuteen_US
dc.subjectToxicityen_US
dc.subjectHerbalen_US
dc.subjectHIVen_US
dc.titleAcute and Sub-acute Toxicity Evaluation in Rats of PPOJ5 and ADOJ6 Herbal Remedies Used Traditionally in the Management of HIV Infectionen_US
dc.typeArticleen_US
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