Association of Medical Male Circumcision and Antiretroviral Therapy Scale-up With Community HIV Incidence in Rakai,Uganda

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dc.contributor.authorKong, Xiangrong
dc.contributor.authorKigozi, Godfrey
dc.contributor.authorSsekasanvu, Joseph
dc.contributor.authorNalugoda, Fred
dc.contributor.authorNakigozi, Gertrude
dc.contributor.authorNdyanabo, Anthony
dc.contributor.authorLutalo, Tom
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorSsekubugu, Robert
dc.contributor.authorKagaayi, Joseph
dc.contributor.authorBugos, Eva
dc.contributor.authorChang, Larry W.
dc.contributor.authorNanlesta, Pilgrim
dc.contributor.authorMary, Grabowski
dc.contributor.authorBerman, Amanda
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorSerwadda, David
dc.contributor.authorWawer, Maria J.
dc.contributor.authorGray, Ronald H.
dc.date.accessioned2022-03-11T07:00:13Z
dc.date.available2022-03-11T07:00:13Z
dc.date.issued2016
dc.description.abstractRandomized trials have shown that medical male circumcision( MMC)reduces maleHIVacquisition by50% to 60%,1-3 and that early initiation of antiretroviral therapy (ART) reduces HIV transmission by more than90%in HIV-discordant couples.4Mathematical modeling suggests that these interventions could mitigate the HIV epidemic in sub- Saharan Africa,5-7 but there is limited empirical evidence for the population-level effects of these interventions on HIV incidence in real-world programs. MMC provides direct protection against male HIV acquisition by removing the foreskin, which is rich in HIV target cells.8-10 The potential effect ofMMCon population-level HIV incidence depends on this biological effect, the level ofMMC coverage, risk profiles ofmenacceptingMMC,and whether behavioral disinhibition occurs following circumcision.en_US
dc.identifier.citationKong, X., Kigozi, G., Ssekasanvu, J., Nalugoda, F., Nakigozi, G., Ndyanabo, A., ... & Gray, R. H. (2016). Association of medical male circumcision and antiretroviral therapy scale-up with community HIV incidence in Rakai, Uganda. Jama, 316(2), 182-190. doi:10.1001/jama.2016.7292en_US
dc.identifier.other10.1001/jama.2016.7292
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2677
dc.language.isoenen_US
dc.publisherAmerican Medical Associationen_US
dc.subjectMedical Male Circumcisionen_US
dc.subjectAntiretroviral Therapyen_US
dc.subjectCommunityen_US
dc.titleAssociation of Medical Male Circumcision and Antiretroviral Therapy Scale-up With Community HIV Incidence in Rakai,Ugandaen_US
dc.typeArticleen_US
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