Children with disabilities lack access to nutrition, health and WASH services: A secondary data analysis

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dc.contributor.authorChebli, Djenna
dc.contributor.authorDhaif, Fatema
dc.contributor.authorRidha, Ali
dc.contributor.authorSchade, Alexander
dc.contributor.authorKhatri, Chetan
dc.date.accessioned2024-07-03T10:20:39Z
dc.date.available2024-07-03T10:20:39Z
dc.date.issued2024-07
dc.description.abstractOpen tibia fractures are devastating, life changing injuries, with infection associated with substantial morbidity to the patient. Reducing infection is a research priority, but before interventional studies can be designed, the incidence of infection following this injury needs to be better defined. Our aim was to estimate the global incidence of infection following an open tibia fracture. A systematic review was performed of MEDLINE, EMBASE, Central Register of Controlled Trials (CENTRAL), Web of Science and Global Index Medicus. We included randomised controlled trials with more than ten participants which reported infections after open diaphyseal or distal fractures (AO 42 or 43). Primary outcome was deep infection according to the Centres for Disease Control and Prevention criteria. Secondary outcome included causative micro-organisms. A meta-analysis using a random effects model to assess incidence and between-treatment effects was performed. Thirteen studies including 1463 adults from seven middle-income countries, seven high-income countries and one low-income country were included. The incidence of infection was 12.12 person-years (95% CI 7.95-18.47). A subgroup analysis compared external fixation and intramedullary nailing showed no difference between infection rates. There were limited data on organisms, but Staphylococcus aureus was the most commonly identified. There are limited to no data on antimicrobial resistance.Open tibia fractures are devastating, life changing injuries, with infection associated with substantial morbidity to the patient. Reducing infection is a research priority, but before interventional studies can be designed, the incidence of infection following this injury needs to be better defined. Our aim was to estimate the global incidence of infection following an open tibia fracture. A systematic review was performed of MEDLINE, EMBASE, Central Register of Controlled Trials (CENTRAL), Web of Science and Global Index Medicus. We included randomised controlled trials with more than ten participants which reported infections after open diaphyseal or distal fractures (AO 42 or 43). Primary outcome was deep infection according to the Centres for Disease Control and Prevention criteria. Secondary outcome included causative micro-organisms. A meta-analysis using a random effects model to assess incidence and between-treatment effects was performed. Thirteen studies including 1463 adults from seven middle-income countries, seven high-income countries and one low-income country were included. The incidence of infection was 12.12 person-years (95% CI 7.95-18.47). A subgroup analysis compared external fixation and intramedullary nailing showed no difference between infection rates. There were limited data on organisms, but Staphylococcus aureus was the most commonly identified. There are limited to no data on antimicrobial resistance. MEDLINE - Academic
dc.identifier.citationChebli, Djenna, Fatema Dhaif, Ali Ridha, et al. 'A Meta-Analysis of the Incidence of Infections Following Open Tibia Fractures and the Microorganisms that Cause them in High-, Middle- and Low-Income Countries', Tropical Doctor, vol. 54/no. 3, (2024), pp. 272-281.
dc.identifier.issnISSN 0049-4755, 1758-1133
dc.identifier.issnEISSN 1758-1133
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9585
dc.language.isoen
dc.publisherSAGE Publications
dc.titleChildren with disabilities lack access to nutrition, health and WASH services: A secondary data analysis
dc.typeArticle
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