Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

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dc.contributor.authorOmara, Timothy
dc.contributor.authorKiprop, Ambrose K.
dc.contributor.authorRamkat, Rose C.
dc.contributor.authorCherutoi, Jackson
dc.contributor.authorKagoya, Sarah
dc.contributor.authorMoraa Nyangena, Decrah
dc.contributor.authorAzeze Tebo, Tsedey
dc.contributor.authorNteziyaremye, Papias
dc.contributor.authorNyambura Karanja, Lucy
dc.contributor.authorJepchirchir, Abigael
dc.contributor.authorMaiyo, Alfayo
dc.contributor.authorJematia Kiptui, Betty
dc.contributor.authorMbabazi, Immaculate
dc.contributor.authorKiwanuka Nakiguli, Caroline
dc.contributor.authorNakabuye, Brenda Victoria
dc.contributor.authorChepkemoi Koske, Margaret
dc.date.accessioned2023-04-14T18:38:30Z
dc.date.available2023-04-14T18:38:30Z
dc.date.issued2020
dc.description.abstract)e burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with reported anticancer activity used in rural Uganda and the evidences supporting their use in cancer therapy. An electronic survey in multidisciplinary databases revealed that 29 plant species belonging to 28 genera distributed among 24 families have been reported to be used in the management of cancer in Uganda. Anticancer plants were majorly from the families Bignoniaceae (7%), Caricaceae (7%), Fabaceae (7%), Moraceae (7%), and Rutaceae (7%). Most species occur in the wild (52%), though some are cultivated (48%). )e growth habit of the plants is as trees (55%) or herbs (45%). Anticancer extracts are usually prepared from leaves (29%), bark (24%), roots (21%), and fruits (13%) through decoctions (53%), as food spices (23%) or pounded to produce ointments that are applied topically (10%). Prunus africana (Hook.f.) Kalkman, Opuntia species, Albizia coriaria (Welw. ex Oliver), Daucus carota L., Cyperus alatus (Nees) F. Muell., Markhamia lutea (Benth.) K. Schum., and Oxalis corniculata L. were the most frequently encountered species. As per global reports, Allium sativum L., Annona muricata L., Carica papaya L., Moringa oleifera Lam., Opuntia species, Prunus africana (Hook.f.) Kalkman, and Catharanthus roseus (L.) G. Don. are the most studied species, with the latter having vincristine and vinblastine anticancer drugs developed from it. Prostate, cervical, breast, and skin cancers are the top traditionally treated malignancies. )ere is a need to isolate and evaluate the anticancer potential of the bioactive compounds in the unstudied claimed plants, such as Cyperus alatus (Nees) F. Muell., Ficus dawei Hutch., Ficus natalensis Hochst., and Lovoa trichilioides Harms, and elucidate their mechanism of anticancer activity.en_US
dc.identifier.citationOmara, T., Kiprop, A. K., Ramkat, R. C., Cherutoi, J., Kagoya, S., Moraa Nyangena, D., ... & Chepkemoi Koske, M. (2020). Medicinal plants used in traditional management of cancer in Uganda: a review of ethnobotanical surveys, phytochemistry, and anticancer studies. Evidence-Based Complementary and Alternative Medicine, 2020, 1-26.en_US
dc.identifier.urihttps://doi.org/10.1155/2020/3529081
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8479
dc.language.isoenen_US
dc.publisherEvidence-Based Complementary and Alternative Medicineen_US
dc.subjectMedicinal Plantsen_US
dc.subjectTraditional Managementen_US
dc.subjectCanceren_US
dc.subjectEthnobotanical Surveysen_US
dc.subjectPhytochemistryen_US
dc.subjectAnticancer Studiesen_US
dc.titleMedicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studiesen_US
dc.typeArticleen_US
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