Prevalence of Aspergillus Fumigatus Skin Positivity in Adults without an apparent/known Atopic Disease in Uganda

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dc.contributor.authorKwizera, Richard
dc.contributor.authorBongomin, Felix
dc.contributor.authorOlum, Ronald
dc.contributor.authorWorodria, William
dc.contributor.authorMeya, David B.
dc.contributor.authorKirenga, Bruce J.
dc.contributor.authorGore, Robin
dc.contributor.authorDenning, David W.
dc.date.accessioned2022-08-18T18:13:42Z
dc.date.available2022-08-18T18:13:42Z
dc.date.issued2021
dc.description.abstractSkin prick testing (SPT) is an important investigation in the evaluation of allergy to fungal pathogens. However, the background sensitivity to fungal allergens among healthy people in Uganda is unknown. Our aim was to assess the background prevalence of Aspergillus fumigatus SPT positivity in apparently healthy adults without known atopic disease in Uganda. For this pilot study, we recruited 50 healthy volunteers using convenience sampling, 56% of whom were health workers. We performed the SPT for A. fumigatus according to manufacturer’s instructions. A wheal diameter of ⩾3 mm was considered positive. The prevalence of A. fumigatus skin positivity was 60% (30/50). Participants with a positive A. fumigatus SPT were significantly younger than those with a negative result [median age (years): 28 versus 35; p = 0.005].There is a high skin positivity against A. fumigatus among non-atopic healthy Ugandan adults. There is an urgent need to establish a normal wheal cut-off value for this population. SPT alone may be an unreliable test for the diagnosis of A. fumigatus associated allergic syndromes. More studies are needed to define the prevalence of A. fumigatus skin positivity among non-atopic healthy population in Africa.en_US
dc.identifier.citationKwizera, R., Bongomin, F., Olum, R., Worodria, W., Bwanga, F., Meya, D. B., ... & Denning, D. W. (2021). Prevalence of Aspergillus fumigatus skin positivity in adults without an apparent/known atopic disease in Uganda. Therapeutic advances in infectious disease, 8, 20499361211039040.https://doi.org/10.1177%2F20499361211039040en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4294
dc.language.isoenen_US
dc.publisherTherapeutic advances in infectious diseaseen_US
dc.subjectAspergillus sensitisation, atopy, fungal allergy, skin prick testing, Ugandaen_US
dc.titlePrevalence of Aspergillus Fumigatus Skin Positivity in Adults without an apparent/known Atopic Disease in Ugandaen_US
dc.typeArticleen_US
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