Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda

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dc.contributor.authorBoon, Denali
dc.contributor.authorRedd, Andrew D.
dc.contributor.authorLaeyendecker, Oliver
dc.contributor.authorEngle, Ronald E.
dc.contributor.authorNguyen, Hanh
dc.contributor.authorOcama, Ponsiano
dc.contributor.authorBoaz, Iga
dc.contributor.authorNdyanabo, Anthony
dc.contributor.authorKiggundu, Valerian
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorGray, Ronald H.
dc.contributor.authorWawer, Maria J.
dc.contributor.authorPurcell, Robert H.
dc.contributor.authorKirk, Gregory D.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorStabinski, Lara
dc.date.accessioned2022-04-30T20:37:03Z
dc.date.available2022-04-30T20:37:03Z
dc.date.issued2018
dc.description.abstractA cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071–1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090–1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852–1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.en_US
dc.identifier.citationBoon, D., Redd, A. D., Laeyendecker, O., Engle, R. E., Nguyen, H., Ocama, P., ... & Rakai Health Sciences Program. (2018). Hepatitis E virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District, Uganda. The Journal of Infectious Diseases, 217(5), 785-789. DOI: 10.1093/infdis/jix610en_US
dc.identifier.other10.1093/infdis/jix610
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3074
dc.language.isoenen_US
dc.publisherThe Journal of Infectious Diseasesen_US
dc.subjecthepatitis E virusen_US
dc.subjectViral hepatitisen_US
dc.subjectHEV seroprevalenceen_US
dc.subjectUgandaen_US
dc.subjectRakaien_US
dc.titleHepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Ugandaen_US
dc.typeArticleen_US
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