Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Biomedical Applications
Abstract
In this paper we present recent advances in Förster resonance energy transfer (FRET) sensing and bioimaging using
nontoxic silicon quantum dots. (SiQDs) In our work, we prepare SiQDs-dye conjugates, with SiQDs serving as the donor
which are covalently attached to organic dye acceptors via self-assembled monolayer linkers. Enzymatic cleavage of the
peptide leads to changes in FRET response which was monitored using fluorescence lifetime imaging microscopy
(FLIM-FRET). The combination of interfacial design and optical imaging presented in this work opens new
opportunities for bio-applications using nontoxic silicon quantum dots.
Description
Keywords
Quantum, Dots, Silicon, FRET, FLIM, Sensor
Citation
Xiaoyu Cheng, Benjamin F. P. McVey, Andrew B. Robinson, Guillaume Longatte, Peter B. O’Mara, Vincent T. G. Tan, Pall Thordarson, Richard D. Tilley, Katharina Gaus, J. Justin Gooding, "Colloidal silicon quantum dots: from preparation to the modification of self-assembled monolayers for bioimaging and sensing applications," Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 100780O (22 February 2017); doi: 10.1117/12.2249592