Stochastic Model for Langerhans Cells and HIV Dynamics In Vivo

dc.contributor.author	Mbogo, Waema R.
dc.contributor.author	Luboobi, Livingstone S.
dc.contributor.author	Odhiambo, John.W.
dc.date.accessioned	2022-06-15T20:26:53Z
dc.date.available	2022-06-15T20:26:53Z
dc.date.issued	2014
dc.description.abstract	Many aspects of the complex interaction between HIV and the human immune system remain elusive. Our objective is to study these interactions, focusing on the specific roles of Langerhans cells (LCs) in HIV infection. In patients infected with HIV, a large amount of virus is associated with LCs in lymphoid tissue. To assess the influence of LCs on HIV viral dynamics during antiretroviral therapy, we present and analyse a stochastic model describing the dynamics of HIV, CD+4 T cells, and LCs interactions under therapeutic intervention in vivo and show that LCs play an important role in enhancing and spreading initial HIV infection. We perform sensitivity analyses on the model to determine which parameters and/or which interaction mechanisms strongly affect infection dynamics.	en_US
dc.identifier.citation	Mbogo, W. R., Luboobi, L. S., & Odhiambo, J. W. (2014). Stochastic model for langerhans cells and HIV dynamics in vivo. International Scholarly Research Notices, 2014.http://dx.doi.org/10.1155/2014/594617	en_US
dc.identifier.uri	https://nru.uncst.go.ug/handle/123456789/3980
dc.language.iso	en	en_US
dc.publisher	International Scholarly Research Notice	en_US
dc.title	Stochastic Model for Langerhans Cells and HIV Dynamics In Vivo	en_US
dc.type	Article	en_US

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