Nodding Syndrome in Uganda is aTauopathy

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dc.contributor.authorPollanen, Michael S.
dc.contributor.authorOnzivua, Sylvester
dc.contributor.authorRobertson, Janice
dc.contributor.authorMcKeever, Paul M.
dc.contributor.authorOlawa, Francis
dc.contributor.authorKitara, David L.
dc.contributor.authorFong, Amanda
dc.date.accessioned2022-06-01T19:22:26Z
dc.date.available2022-06-01T19:22:26Z
dc.date.issued2018
dc.description.abstractNodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13–18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic examination revealed tau-immunoreactive neuronal neurofibrillary tangles, pre-tangles, neuropil threads, and dot-like lesions involving the cerebral cortex, subcortical nuclei and brainstem. There was preferential involvement of the frontal and temporal lobes in a patchy distribution, mostly involving the crests of gyri and the superficial cortical lamina. The mesencephalopontine tegmental nuclei, substantia nigra, and locus coeruleus revealed globose neurofibrillary tangles and threads. We conclude that nodding syndrome is a tauopathy and may represent a newly recognized neurodegenerative disease.en_US
dc.identifier.citationPollanen, M. S., Onzivua, S., Robertson, J., McKeever, P. M., Olawa, F., Kitara, D. L., & Fong, A. (2018). Nodding syndrome in Uganda is a tauopathy. Acta neuropathologica, 136(5), 691-697.https://doi.org/10.1007/s00401-018-1909-9en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3649
dc.language.isoenen_US
dc.publisherActa neuropathologicaen_US
dc.subjectNeurodegeneration · Neurofibrillary tangles · Progressive supranuclear palsyen_US
dc.titleNodding Syndrome in Uganda is aTauopathyen_US
dc.typeArticleen_US
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