Prevalence of antibiotic-resistant bacteria among patients in two tertiary hospitals in Eastern Uganda

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dc.contributor.authorObakiro, Samuel Baker
dc.contributor.authorKiyimba, Kenedy
dc.contributor.authorPaasi, George
dc.contributor.authorNapyo, Agnes
dc.contributor.authorAnthierens, Sibyl
dc.contributor.authorWaako, Paul
dc.contributor.authorRoyen, Paul Van
dc.contributor.authorIramiot, Jacob Stanley
dc.contributor.authorGoossens, Herman
dc.contributor.authorKostyanev, Tomislav
dc.date.accessioned2023-02-26T11:58:53Z
dc.date.available2023-02-26T11:58:53Z
dc.date.issued2021
dc.description.abstractThe aim of this study was to determine the prevalence and antibiotic resistance patterns of bacterial isolates from inpatients and outpatients in Mbale and Soroti regional referral hospitals in Eastern Uganda. Methods: A retrospective analysis of culture and antibiotic sensitivity test results from the microbiology laboratories of the two tertiary hospitals was conducted for a 3-year period (January 2016–December 2018). Results: Microbiology records of 3092 patients were reviewed and analysed, with 1305 (42.1%) samples yielding clinical isolates. The most prevalent isolates were Escherichia coli (n = 442; 33.9%), Staphylococcus aureus (n = 376; 28.8%), Klebsiella pneumoniae (n = 237; 18.2%), and Streptococcus pneumoniae (n = 76; 5.8%). High rates of antimicrobial resistance were detected across both Gram-negative and Gram-positive bacteria. Escherichia coli and K. pneumoniae were resistant to several agents such as amoxicillin/ clavulanate (83.5%; 64.6%), cefotaxime (74.2%; 52.7%), ciprofloxacin (92.1%; 27.8%), gentamicin (51.8%; 76%), imipenem (3.2%; 10.5%), tetracycline (98%; 74.5%), and trimethoprim-sulfamethoxazole (74.1%; 74.3%), respectively. Staphylococcus aureus and S. pneumoniae exhibited the following resistance profile: cefoxitin (44.4%; 40.9%), chloramphenicol (69.1%; 27.6%) clindamycin (21.5%; 24.4%), gentamicin (83.2%; 66.9%), penicillin (46.5%; -) tetracycline (85.6%; 97.6%), trimethoprim-sulfamethoxazole (88%; 91.3%), and vancomycin (41.2%; -). Conclusion: We observed high resistance rates to antibiotics among the majority of microorganisms that were isolated from the samples collected from patients in Eastern Uganda. Furthermore, measures should be undertaken locally to improve microbiology diagnostics and to prevent the spread of antibiotic-resistant strains as this impedes the optimal treatment of bacterial infections and narrows the choice of effective therapeutic options.en_US
dc.identifier.citationObakiro, S. B., Kiyimba, K., Paasi, G., Napyo, A., Anthierens, S., Waako, P., ... & Kostyanev, T. (2021). Prevalence of antibiotic-resistant bacteria among patients in two tertiary hospitals in Eastern Uganda. Journal of Global Antimicrobial Resistance, 25, 82-86. http://dx.doi.org/10.1016/j.jgar.2021.02.021en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jgar.2021.02.021
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7994
dc.language.isoenen_US
dc.publisherJournal of Global Antimicrobial Resistanceen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectAntibioticsen_US
dc.subjectBacterial infectionsen_US
dc.subjectMicrobiologyen_US
dc.titlePrevalence of antibiotic-resistant bacteria among patients in two tertiary hospitals in Eastern Ugandaen_US
dc.typeArticleen_US
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