The Etiology of Pneumonia From Analysis of Lung Aspirate and Pleural Fluid Samples: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study

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dc.contributor.authorEbruke, Bernard E.
dc.contributor.authorDeloria Knoll, Maria
dc.contributor.authorHaddix, Meredith
dc.contributor.authorZaman, Syed M. A.
dc.contributor.authorProsperi, Christine
dc.contributor.authorFeikin, Daniel R.
dc.contributor.authorHammitt, Laura L.
dc.contributor.authorLevine, Orin S.
dc.contributor.authorO’Brien, Katherine L.
dc.contributor.authorMurdoch, David R.
dc.contributor.authorBrooks, W. Abdullah
dc.contributor.authorScott, J. Anthony G.
dc.contributor.authorKotloff, Karen L.
dc.contributor.authorMadhi, Shabir A.
dc.contributor.authorThea, Donald M.
dc.contributor.authorBaillie, Vicky L.
dc.contributor.authorJobayer Chisti, Mohammod
dc.contributor.authorDione, Michel
dc.contributor.authorDriscoll, Amanda J.
dc.contributor.authorFancourt, Nicholas
dc.contributor.authorKarron, Ruth A.
dc.contributor.authorLe, Tham T.
dc.contributor.authorMohamed, Shebe
dc.contributor.authorMoore, David P.
dc.contributor.authorMorpeth, Susan C.
dc.contributor.authorMwaba, John
dc.contributor.authorMwansa, James
dc.contributor.authorSayeem Bin Shahid, Abu Sadat Mohammad
dc.contributor.authorSow, Samba O.
dc.contributor.authorTapia, Milagritos D.
dc.contributor.authorAntonio, Martin
dc.contributor.authorHowie, Stephen R. C.
dc.date.accessioned2022-02-13T20:32:26Z
dc.date.available2022-02-13T20:32:26Z
dc.date.issued2021
dc.description.abstractAn improved understanding of childhood pneumonia etiology is required to inform prevention and treatment strategies. Lung aspiration is the gold standard specimen for pneumonia diagnostics. We report findings from analyses of lung and pleural aspirates collected in the Pneumonia Etiology Research for Child Health (PERCH) study. Methods. The PERCH study enrolled children aged 1–59 months hospitalized with World Health Organization–defined severe or very severe pneumonia in 7 countries in Africa and Asia. Percutaneous transthoracic lung aspiration (LA) and pleural fluid (PF) aspiration was performed on a sample of pneumonia cases with radiological consolidation and/or PF in 4 countries. Venous blood and nasopharyngeal/oropharyngeal swabs were collected from all cases. Multiplex quantitative polymerase chain reaction (PCR) and routine microbiologic culture were applied to clinical specimens. Results. Of 44 LAs performed within 3 days of admission on 622 eligible cases, 13 (30%) had a pathogen identified by either culture (5/44) or by PCR (11/29). A pathogen was identified in 12/14 (86%) PF specimens tested by either culture (9/14) or PCR (9/11). Bacterial pathogens were identified more frequently than viruses. All but 1 of the cases with a virus identified were coinfected with bacterial pathogens. Streptococcus pneumoniae (9/44 [20%]) and Staphylococcus aureus (7/14 [50%]) were the predominant pathogens identified in LA and PF, respectively. Conclusions. Bacterial pathogens predominated in this selected subgroup of PERCH participants drawn from those with radiological consolidation or PF, with S. pneumoniae and S. aureus the leading pathogens identified.en_US
dc.identifier.citationEbruke, B. E., Deloria Knoll, M., Haddix, M., Zaman, S. M., Prosperi, C., Feikin, D. R., ... & Howie, S. R. (2021). The Etiology of Pneumonia From Analysis of Lung Aspirate and Pleural Fluid Samples: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. Clinical Infectious Diseases, 73(11), e3788-e3796. DOI: 10.1093/cid/ciaa1032en_US
dc.identifier.other10.1093/cid/ciaa1032
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2096
dc.language.isoenen_US
dc.publisherClinical Infectious Diseasesen_US
dc.subjectLung aspirateen_US
dc.subjectPleural fluid aspirateen_US
dc.subjectPERCHen_US
dc.subjectPneumoniaen_US
dc.subjectEtiology childhooden_US
dc.titleThe Etiology of Pneumonia From Analysis of Lung Aspirate and Pleural Fluid Samples: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Studyen_US
dc.typeArticleen_US
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