Context matters: PrEP adherence is associated with sexual behavior among HIV serodiscordant couples in East Africa

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dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorNgure, Kenneth
dc.contributor.authorMuwonge, Timothy
dc.contributor.authorMugo, Nelly
dc.contributor.authorKatabira, Elly
dc.contributor.authorHeffron, Renee
dc.contributor.authorMusinguzi, Nicholas
dc.contributor.authorBangsberg, David R.
dc.contributor.authorCelum, Connie
dc.contributor.authorBaeten, Jared M.
dc.date.accessioned2023-02-07T18:58:27Z
dc.date.available2023-02-07T18:58:27Z
dc.date.issued2017
dc.description.abstractShort message service (SMS) surveys are a promising tool for understanding whether pre-exposure prophylaxis (PrEP) adherence aligns with risk for HIV acquisition— a concept known as prevention-effective adherence. Methods—The Partners Demonstration Project was an open-label study of integrated PrEP and antiretroviral therapy (ART) delivery among high-risk HIV serodiscordant couples in East Africa. HIV-uninfected partners were offered PrEP until their HIV-infected partner had taken ART for ≥6 months. At 2 study sites, HIV-uninfected partners were offered enrollment into the Partners Mobile Adherence to PrEP (PMAP) sub-study based on ongoing PrEP use, personal cell phone ownership, and ability to use SMS. SMS surveys asked about PrEP adherence and sexual activity in the prior 24 hours; these surveys were sent daily for the 7 days prior and 7 days after routine study visits in the Partners Demonstration Project. Results—The PMAP sub-study enrolled 373 HIV-uninfected partners; 69% were male and mean age was 31 years. Participants completed 17,030 of 23,056 SMS surveys sent (74%) with a mean of 47 surveys per participant over 9.8 months of follow-up. While HIV-infected partner use of ART was <6 months, mean reported PrEP adherence was 92% on surveys concurrently reporting sex within the serodiscordant partnership and 84% on surveys reporting no sex (p<0.001). Discussion—SMS surveys provided daily assessment of concurrent PrEP adherence and sexual behavior. Higher PrEP adherence was temporally associated with increased risk for HIV acquisition.en_US
dc.identifier.citationHaberer, J. E., Ngure, K., Muwonge, T., Mugo, N., Katabira, E., Heffron, R., ... & Baeten, J. M. (2017). Context matters: PrEP adherence is associated with sexual behavior among HIV serodiscordant couples in East Africa. Journal of acquired immune deficiency syndromes (1999), 76(5), 488. doi:10.1097/QAI. 0000000000001548.en_US
dc.identifier.other10.1097/QAI. 0000000000001548.
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7633
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectHIVen_US
dc.subjectPre-exposure prophylaxis (PrEP)en_US
dc.subjectSMSen_US
dc.subjectAdherenceen_US
dc.titleContext matters: PrEP adherence is associated with sexual behavior among HIV serodiscordant couples in East Africaen_US
dc.typeArticleen_US
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