Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2

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dc.contributor.authorWertheim, Joel O.
dc.contributor.authorHostager, Reilly
dc.contributor.authorRyu, Diane
dc.contributor.authorMerkel, Kevin
dc.contributor.authorAngedakin, Samuel
dc.contributor.authorArandjelovic, Mimi
dc.contributor.authorAyuk Ayimisin, Emmanuel
dc.contributor.authorBabweteera, Fred
dc.contributor.authorYuh, Ginath
dc.contributor.authorLeendertz, Fabian H.
dc.contributor.authorCalvignac-Spencer, Sebastien
dc.date.accessioned2022-11-27T11:22:34Z
dc.date.available2022-11-27T11:22:34Z
dc.date.issued2021
dc.description.abstractViruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and crossspecies transmission. We report the discovery of novel herpes simplexviruses during a large-scale screening of fecal samples from wild gorillas, bonobos, and chimpanzees. Phylogenetic analysis indicates that, contrary to expectation, simplexviruses from these African apes are all more closely related to HSV-2 than to HSV-1. Molecular clock-based hypothesis testing suggests the divergence between HSV-1 and the African great ape simplexviruses likely represents a codivergence event between humans and gorillas. The simplexviruses infecting African great apes subsequently experiencedmultiple cross-species transmission events over the past 3My, the most recent of which occurred between humans and bonobos around 1Ma. These findings revise our understanding of the origins of human herpes simplexviruses and suggest that HSV-2 is one of the earliest zoonotic pathogens.en_US
dc.identifier.citationWertheim, J. O., Hostager, R., Ryu, D., Merkel, K., Angedakin, S., Arandjelovic, M., ... & Calvignac-Spencer, S. (2021). Discovery of novel herpes simplexviruses in wild gorillas, bonobos, and chimpanzees supports zoonotic origin of HSV-2. Molecular biology and evolution, 38(7), 2818-2830. doi:10.1093/molbev/msab072en_US
dc.identifier.other10.1093/molbev/msab072
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/5462
dc.language.isoenen_US
dc.publisherMolecular biology and evolutionen_US
dc.subjectphylogeneticsen_US
dc.subjectZoonosisen_US
dc.subjectHerpesvirusen_US
dc.subjectMolecular clocken_US
dc.subjectApeen_US
dc.titleDiscovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2en_US
dc.typeArticleen_US
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