Assessing the external validity of a randomized controlled trial of anthelminthic in mothers and their children in Entebbe, Uganda

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dc.contributor.authorMillard, James D.
dc.contributor.authorMuhangi, Lawrence
dc.contributor.authorSewankambo, Moses
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorElliott, Alison M.
dc.contributor.authorWebb, Emily L.
dc.date.accessioned2022-01-30T09:25:14Z
dc.date.available2022-01-30T09:25:14Z
dc.date.issued2014
dc.description.abstractThe ‘external validity’ of randomized controlled trials is an important measure of quality, but is often not formally assessed. Trials concerning mass drug administration for helminth control are likely to guide public health policy and careful interpretation of their context is needed. We aimed to determine how representative participants in one such trial were of their community. We explore implications for trial interpretation and resulting public health recommendations. The trial assessed was the Entebbe Mother and Baby Study (EMaBS), a trial of anthelminthic treatment during pregnancy and early childhood. In a novel approach for assessing external validity, we conducted a two-stage cluster sample community survey within the trial catchment area and compared characteristics of potentially-eligible community children with characteristics of children participating in the trial.en_US
dc.identifier.citationMillard et al.: Assessing the external validity of a randomized controlled trial of anthelminthics in mothers and their children in Entebbe, Uganda. Trials 2014 15:310. doi:10.1186/1745-6215-15-310en_US
dc.identifier.other10.1186/1745-6215-15-310
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1617
dc.language.isoenen_US
dc.publisherTrialsen_US
dc.subjectHelminthsen_US
dc.subjectAnthelminthicsen_US
dc.subjectExternal validityen_US
dc.subjectGeneralizabilityen_US
dc.subjectCluster sample community surveyen_US
dc.subjectUgandaen_US
dc.titleAssessing the external validity of a randomized controlled trial of anthelminthic in mothers and their children in Entebbe, Ugandaen_US
dc.typeArticleen_US
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