Are rapid diagnostic tests more accurate in diagnosis of plasmodium falciparum malaria compared to microscopy at rural health centres?

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dc.contributor.authorBatwala, Vincent
dc.contributor.authorMagnussen, Pascal
dc.contributor.authorNuwaha, Fred
dc.date.accessioned2021-12-13T20:03:58Z
dc.date.available2021-12-13T20:03:58Z
dc.date.issued2010
dc.description.abstractPrompt, accurate diagnosis and treatment with artemisinin combination therapy remains vital to current malaria control. Blood film microscopy the current standard test for diagnosis of malaria has several limitations that necessitate field evaluation of alternative diagnostic methods especially in low income countries of sub-Saharan Africa where malaria is endemic. The accuracy of axillary temperature, health centre (HC) microscopy, expert microscopy and a HRP2- based rapid diagnostic test (Paracheck) was compared in predicting malaria infection using polymerase chain reaction (PCR) as the gold standard. Three hundred patients with a clinical suspicion of malaria based on fever and or history of fever from a low and high transmission setting in Uganda were consecutively enrolled and provided blood samples for all tests. Accuracy of each test was calculated overall with 95% confidence interval and then adjusted for age-groups and level of transmission intensity using a stratified analysis. The endpoints were: sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). This study is registered with Clinicaltrials.gov, NCT00565071.en_US
dc.identifier.citationBatwala, V., Magnussen, P., & Nuwaha, F. (2010). Are rapid diagnostic tests more accurate in diagnosis of plasmodium falciparum malaria compared to microscopy at rural health centres?. Malaria journal, 9(1), 1-8. https://doi.org/10.1186/1475-2875-9-349en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/453
dc.language.isoenen_US
dc.publisherMalaria journalen_US
dc.subjectPolymerase Chain Reaction Malaria Positive Predictive Value Negative Predictive Value Malaria Infectionen_US
dc.titleAre rapid diagnostic tests more accurate in diagnosis of plasmodium falciparum malaria compared to microscopy at rural health centres?en_US
dc.typeArticleen_US
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