Feasibility of a multifaceted intervention to improve treatment initiation among patients diagnosed with TB using Xpert MTB/RIF testing in Uganda

Simple item page
dc.contributor.authorZawedde-Muyanja, Stella
dc.contributor.authorMusaazi, Joseph
dc.contributor.authorCastelnuovo, Barbara
dc.contributor.authorCattamanchi, Adithya
dc.contributor.authorKatamba, Achilles
dc.contributor.authorManabe, Yukari C.
dc.date.accessioned2023-01-18T16:24:32Z
dc.date.available2023-01-18T16:24:32Z
dc.date.issued2022
dc.description.abstractOne in five patients diagnosed with TB in Uganda are not initiated on TB treatment within two weeks of diagnosis. We evaluated a multifaceted intervention for improving TB treatment initiation among patients diagnosed with TB using Xpert® MTB/RIF testing in Uganda. Methods This was a pre-post interventional study at one tertiary referral hospital. The intervention was informed by the COM-B model and included; i) medical education sessions to improve healthcare worker knowledge about the magnitude and consequences of pretreatment loss to follow-up; ii) modified laboratory request forms to improve recording of patient contact information; and iii) re-designed workflow processes to improve timeliness of sputum testing and results dissemination. TB diagnostic process and outcome data were collected and compared from the period before (June to August 2019) and after (October to December 2019) intervention initiation. Results In September 2019, four CME sessions were held at the hospital and were attended by 58 healthcare workers. During the study period, 1242 patients were evaluated by Xpert® MTB/ RIF testing at the hospital (679 pre and 557 post intervention). Median turnaround time for sputum test results improved from 12 hours (IQR 4–46) in the pre-intervention period to 4 hours (IQR 3–6) in the post-intervention period. The proportion of patients started on treatment within two weeks of diagnosis improved from 59% (40/68) to 89% (49/55) (difference 30%, 95% CI 14%-43%, p<0.01) while the proportion of patients receiving a same-day diagnosis increased from 7.4% (5/68) to 25% (14/55) (difference 17.6%, 95% CI 3.9%- 32.7%, p<0.01). Conclusion The multifaceted intervention was feasible and resulted in a higher proportion of patients initiating TB treatment within two weeks of diagnosis.en_US
dc.identifier.citationZawedde-Muyanja S, Musaazi J, Castelnuovo B, Cattamanchi A, Katamba A, Manabe YC (2022) Feasibility of a multifaceted intervention to improve treatment initiation among patients diagnosed with TB using Xpert MTB/RIF testing in Uganda. PLoS ONE 17(6): e0265035. https://doi. org/10.1371/journal.pone.0265035en_US
dc.identifier.urihttps://doi. org/10.1371/journal.pone.0265035
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7033
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectFeasibilityen_US
dc.subjectMultifaceted interventionen_US
dc.subjectTreatment initiationen_US
dc.subjectPatientsen_US
dc.subjectTBen_US
dc.subjectXpert MTB/RIF testingen_US
dc.titleFeasibility of a multifaceted intervention to improve treatment initiation among patients diagnosed with TB using Xpert MTB/RIF testing in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Feasibility of a multifaceted intervention to.pdf
Size:
725.47 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences