Outbreak of gastrointestinal anthrax following eating beef of suspicious origin: Isingiro District, Uganda, 2017.

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dc.contributor.authorMiriam, Nakanwagi
dc.contributor.authorAlex, Riolexus Ario
dc.contributor.authorLeocadia, Kwagonza
dc.contributor.authorFreda, Loy Aceng
dc.contributor.authorJames, Mwesigye
dc.contributor.authorLilian, Bulage
dc.contributor.authorJoshua, Buule
dc.contributor.authorJuliet Nsimire, Sendagala
dc.contributor.authorRobert, Downing
dc.contributor.authorBao-Ping, Zhu
dc.date.accessioned2023-01-11T12:07:54Z
dc.date.available2023-01-11T12:07:54Z
dc.date.issued2020-02
dc.description.abstractINTRODUCTION:Gastrointestinal anthrax is a rare but serious disease. In August 2017, Isingiro District, Uganda reported a cluster of >40 persons with acute-onset gastroenteritis. Symptoms included bloody diarrhoea. We investigated to identify the etiology and exposures, and to inform control measures. METHODS:We defined a suspected case as acute-onset of diarrhoea or vomiting during 15-31 August 2017 in a resident (agedā‰„2 years) of Kabingo sub-county, Isingiro District; a confirmed case was a suspected case with a clinical sample positive for Bacillus anthracis by culture or PCR. We conducted descriptive epidemiology to generate hypotheses. In a case-control study, we compared exposures between case-patients and neighbourhood-matched controls. We used conditional logistic regression to compute matched odds ratios (MOR) for associations of illness with exposures. RESULTS:We identified 61 cases (58 suspected and 3 confirmed; no deaths). In the case-control study, 82% of 50 case-patients and 12% of 100 controls ate beef purchased exclusively from butchery X during the week before illness onset (MOR = 46, 95%CI = 4.7-446); 8.0% of case-patients and 3.0% of controls ate beef purchased from butchery X and elsewhere (MOR = 19, 95%CI = 1.0-328), compared with 6.0% of case-patients and 30% of controls who did not eat beef. B. anthracis was identified in two vomitus and one stool sample. Butchery X slaughtered a sick cow and sold the beef during case-patients' incubation period. CONCLUSION:This gastrointestinal anthrax outbreak occurred due to eating beef from butchery X. We recommended health education, safe disposal of the carcasses of livestock or game animals, and anthrax vaccination for livestock.en_US
dc.identifier.citationNakanwagi, Miriam, Alex Riolexus Ario, Leocadia Kwagonza, et al. 'Outbreak of Gastrointestinal Anthrax Following Eating Beef of Suspicious Origin: Isingiro District, Uganda, 2017', PLoS Neglected Tropical Diseases, vol. 14/no. 2, (2020), pp. e0008026-e0008026.en_US
dc.identifier.issn1935-2727
dc.identifier.issn1935-2735 (Online)
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6868
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.subjectMedicine: Internal medicine: Special situations and conditions: Arctic medicine. Tropical medicine Medicine: Public aspects of medicineen_US
dc.titleOutbreak of gastrointestinal anthrax following eating beef of suspicious origin: Isingiro District, Uganda, 2017.en_US
dc.typeArticleen_US
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