Prevalence of RhD Variants Among Blood Donors At Gulu Regional Blood Bank, Gulu, Northern Uganda

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dc.contributor.authorOjok, Polycarp
dc.contributor.authorOyet, Caesar
dc.contributor.authorWebbo, Fred
dc.contributor.authorMwambi, Bashir
dc.contributor.authorTaremwa, Ivan M.
dc.date.accessioned2022-01-24T16:16:01Z
dc.date.available2022-01-24T16:16:01Z
dc.date.issued2017
dc.description.abstractThe aim of this study was to determine the prevalence of RhD variant phenotypes among voluntary non-remunerated blood donors (VNRBDs) at Gulu Regional Blood Bank (GRBB), Northern Uganda.We conducted a cross-sectional study, in which the first 4.0 mL of ethylenediaminetetraacetic acid (EDTA) blood samples were collected from VNRBDs and typed for their ABO and RhD blood group status using IgM and IgG monoclonal typing antisera, respectively. Blood samples that tested as RhD negative were further investigated for RhD variant phenotypes using indirect antihuman globulin hemagglutination technique.We assayed 138 RhD-negative blood samples obtained from VNRBDs. Of these, 66.7% (n=92) were males. Their median age was 24.4 years (range, 14–33 years). Majority of the participants were of ABO blood group O (62.8%, n=86), followed by A (19.7%, n=27), then B (13.9%, n=19) and least AB (3.6%, n=6). The prevalence of RhD variant phenotypes was 0.7% (n=1; 95% confidence interval, 0.5–0.9). There was no statistical association of RhD variant phenotypes with donor gender, tribe and their ABO blood groups.This study has revealed a high prevalence of RhD variant among blood donors at GRBB in Northern Uganda. It further highlights a potential risk of alloimmunization, as the present blood typing practices do not identify RhD variant phenotypes.en_US
dc.identifier.citationOjok, P., Oyet, C., Webbo, F., Mwambi, B., & Taremwa, I. M. (2017). Prevalence of RhD variants among blood donors at Gulu Regional Blood Bank, Gulu, Northern Uganda. Journal of blood medicine, 8, 151.doi: 10.2147/JBM.S145550en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1508
dc.language.isoenen_US
dc.publisherJournal of blood medicineen_US
dc.subjectRh blood group, D variants, D antigen, weak D, partial D, Ugandaen_US
dc.titlePrevalence of RhD Variants Among Blood Donors At Gulu Regional Blood Bank, Gulu, Northern Ugandaen_US
dc.typeArticleen_US
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