Prescription of Levofloxacin and Moxifloxacin in Select Hospitals in Uganda: A Pilot Study to Assess Guideline Concordance

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dc.contributor.authorNambasa, Victoria
dc.contributor.authorNdagije, Helen B.
dc.contributor.authorSerwanga, Allan
dc.contributor.authorManirakiza, Leonard
dc.contributor.authorAtuhaire, Joanitah
dc.contributor.authorNakitto, Diana
dc.contributor.authorKiguba, Ronald
dc.contributor.authorFigueras, Albert
dc.date.accessioned2023-04-04T18:23:42Z
dc.date.available2023-04-04T18:23:42Z
dc.date.issued2020
dc.description.abstractIn Uganda, national tuberculosis (TB) treatment guidelines were revised to include the newer generation fluoroquinolones among the second-line treatment options for multidrug-resistant TB. This study was designed to analyze if the prescription of these quinolones is compliant with country recommendations. Methods: This was an observational retrospective study of consumption data for 2017 and 2018 across four selected regional referral hospitals. The sources of consumption data were hospital pharmacy stock cards and the dispensing register. The medical files of patients who had been prescribed fluoroquinolones were also assessed to study compliance with the Uganda Clinical Guidelines and the British National Formulary (BNF). Results: None of the 371 levofloxacin prescriptions analyzed complied with the Uganda Clinical Guidelines, although 250 (67.3%) were prescribed for indications included in the BNF. According to WHO prescription indicators, only 220 (59.3%) prescriptions were appropriate. Conclusion: The prescription of levofloxacin and moxifloxacin increased in the hospitals studied, but in a high proportion of cases, they were not compliant with country recommendations. The findings call for the strengthening of national antimicrobial stewardship programs.en_US
dc.identifier.citationNambasa, V., Ndagije, H. B., Serwanga, A., Manirakiza, L., Atuhaire, J., Nakitto, D., ... & Figueras, A. (2020). Prescription of levofloxacin and moxifloxacin in select hospitals in Uganda: a pilot study to assess guideline concordance. Antibiotics, 9(8), 439.https://doi.org/10.3390/antibiotics9080439en_US
dc.identifier.issn2079-6382
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8410
dc.language.isoenen_US
dc.publisherAntibioticsen_US
dc.subjectFluoroquinolonesen_US
dc.subjectPrescription habitsen_US
dc.subjectMultidrug-resistant tuberculosisen_US
dc.subjectDrug utilization studyen_US
dc.titlePrescription of Levofloxacin and Moxifloxacin in Select Hospitals in Uganda: A Pilot Study to Assess Guideline Concordanceen_US
dc.typeArticleen_US
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