Bioactive secondary metabolites from the leaves of Secamone africana (Olive.) Bullock

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dc.contributor.authorSekandi, Peter
dc.contributor.authorNamukobe, Jane
dc.contributor.authorByamukama, Robert
dc.contributor.authorAkala, Hoseah M.
dc.contributor.authorYeda, Redemptah A.
dc.contributor.authorHeydenreich, Matthias
dc.date.accessioned2021-12-13T12:59:53Z
dc.date.available2021-12-13T12:59:53Z
dc.date.issued2020
dc.description.abstractSecamone africana leaves are used in the treatment of malaria and other ailments in Uganda. The aim of the study was to characterize the antiplasmodial compounds from the leaves of Secamone africana. The leaves were extracted sequentially using dichloromethane (DCM) and methanol (MeOH). The crude extracts and isolated compounds were evaluated for their antiplasmodial activity against the chloroquine sensitive Sierraleone I (D6) and chloroquine-resistant Indochina I (W2) strains of Plasmodium falciparum. Isolation and purification were done using chromatographic techniques including column chromatography and high performance liquid chromatography. The isolated compounds were characterized using spectroscopic methods. The MeOH extract (IC50 = 5.45 μg/mL) was found to be more active than the DCM extract (IC50= 15.93 μg/mL) against the D6 malaria parasite. Chemical investigation of the MeOH extract yielded one new compound; 2-(2,4-dimethyloxetan-2-yl) acetic acid (3) in addition to the six known compounds; α-linolenic acid (1), conduritol B (4), β-sitosterol (5), 3,4-dihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7) and coumaric acid (8). The DCM extract yielded one known compound: 1-methyl cyclobutene (2). The presence of these compounds with good anti-plasmodial activities and other bioactivities reported in literature, appears to argue for the therapeutic potential of Secamone africana.en_US
dc.identifier.citationSekandi, P., Namukobe, J., Byamukama, R., Akala, H. M., Yeda, R. A., & Heydenreich, M. (2020). Bioactive secondary metabolites from the leaves of Secamone africana (Olive.) Bullock. International Journal of Biological and Chemical Sciences, 14(5), 1820-1830.DOI : https://doi.org/10.4314/ijbcs.v14i5.25en_US
dc.identifier.issn1997-342X (Online), ISSN 1991-8631 (Print)
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/436
dc.language.isoenen_US
dc.publisherInternational Journal of Biological and Chemical Sciencesen_US
dc.subjectSecamone africanaen_US
dc.subjectAnti-plasmodial activityen_US
dc.subjectChromatographyen_US
dc.subjectSecondary metabolitesen_US
dc.titleBioactive secondary metabolites from the leaves of Secamone africana (Olive.) Bullocken_US
dc.typeArticleen_US
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