Side-Effects following Oxford/AstraZeneca COVID-19 Vaccine in Tororo District, Eastern Uganda: A Cross-Sectional Study
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Date
2022-11
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract
Abstract: Effective, safe and proven vaccines would be the most effective strategy against the
COVID-19 pandemic but have faced rollout challenges partly due to fear of potential side-effects.
We assessed the prevalence, profiles, and predictors of Oxford/AstraZeneca vaccine side-effects
in Tororo district of Eastern Uganda. We conducted telephone interviews with 2204 participants
between October 2021 and January 2022. Multivariable logistic regression was conducted to assess
factors associated with Oxford/AstraZeneca vaccine side-effects using Stata version 15.0. A total of
603/2204 (27.4%) of the participants experienced one or more side-effects (local, systemic, allergic,
and other side-effects). Of these, 253/603 (42.0%) experienced local side-effects, 449/603 (74.5%)
experienced systemic side-effects, 11/603 (1.8%) experienced allergic reactions, and 166/603 (27.5%)
experienced other side-effects. Ten participants declined to receive the second dose because of
side-effects they had experienced after the first dose. Previous infection with COVID-19 (adjusted
odds ratio (AOR): 4.3, 95% confidence interval (95% CI): 2.7–7.0), being female (AOR: 1.3, 95% CI:
1.1–1.6) and being a security officer (AOR: 0.4, 95% CI: 0.2–0.6) were associated with side-effects to the
Oxford/AstraZeneca vaccine. We recommend campaigns to disseminate correct information about
potential side-effects of the Oxford/AstraZeneca vaccine and strengthen surveillance for adverse
events following vaccination.
Description
Keywords
side-effects, COVID-19, Oxford/AstraZeneca vaccine, Uganda
Citation
Onyango, Jagire, David Mukunya, Agnes Napyo, et al. 'Side-Effects Following Oxford/AstraZeneca COVID-19 Vaccine in Tororo District, Eastern Uganda: A Cross-Sectional Study', International Journal of Environmental Research and Public Health, vol. 19/no. 22, (2022), pp. 15303.