Vertical Transmission Of X4-Tropic And Dual-Tropic HIV-1 In Five Ugandan Mother–Infant Pairs

Simple item page
dc.contributor.authorHuang, Wei
dc.contributor.authorEshleman, Susan H.
dc.contributor.authorToma, Jonathan
dc.contributor.authorStawiski, Eric
dc.contributor.authorWhitcomb, Jeannette M.
dc.contributor.authorJackson, J. Brooks
dc.contributor.authorGuay, Laura
dc.contributor.authorMusoke, Philippa
dc.contributor.authorParkin, Neil
dc.contributor.authorPetropoulos, Christos J.
dc.date.accessioned2022-01-31T12:38:26Z
dc.date.available2022-01-31T12:38:26Z
dc.date.issued2009
dc.description.abstractWe previously reported the existence of CXCR4-using HIV-1 in 6–14 week-old Ugandan infants. Whether these viruses were transmitted from the mother perinatally or evolved after transmission is not known. In the current study, we investigated the origin of the CXCR4-using viruses in these infants by comparing HIV-1 envelope clones from the infants to those from their mothers at or near the time of delivery.Envelope clones were isolated from five Ugandan infant plasma samples that harbored CXCR4-using viruses, collected at the time of HIV diagnosis (four at birth, one at week 6), and from their mothers at delivery. Coreceptor usage and phylogenetic relatedness of HIV-1 populations in mother–infant pairs were analyzed in detail using the Trofile assay and sequence analysis of envelope clones, respectively.X4-tropic clones were identified in two mother–infant pairs and dual-tropic clones were found in three pairs, either alone or in combination with R5-tropic viruses. Dual-tropic clones varied in their ability to infect CXCR4-expressing cells. In each mother–infant pair, X4-tropic or dual-tropic clones shared similar phenotypic profiles and V3 sequence patterns; gp160 sequences of X4-tropic and dual-tropic clones from infants were phylogenetically indistinguishable from those of their mothers. The virus populations were phylogenetically homogenous in three infants and segregated according to coreceptor tropism in the remaining two infants.This study demonstrates that X4-tropic and dual-tropic HIV-1 can be transmitted from mother to infant, before, during or shortly after delivery, and establishes vertical transmission as an important source of CXCR4-using viruses in infants.en_US
dc.identifier.citationHuang, W., Eshleman, S. H., Toma, J., Stawiski, E., Whitcomb, J. M., Jackson, J. B., ... & Petropoulos, C. J. (2009). Vertical transmission of X4-tropic and dual-tropic HIV-1 in five Ugandan mother–infant pairs. AIDS (London, England), 23(14), 1903.en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1671
dc.language.isoenen_US
dc.publisherAIDS (London, England)en_US
dc.subjectcoreceptor tropism, CXCR4, HIV, mother-to-child, transmission, X4en_US
dc.titleVertical Transmission Of X4-Tropic And Dual-Tropic HIV-1 In Five Ugandan Mother–Infant Pairsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Vertical Transmission Of X4-Tropic And Dual-Tropic HIV-1 In Five.pdf
Size:
184.72 KB
Format:
Adobe Portable Document Format
Description:
Vertical Transmission Of X4-Tropic And Dual-Tropic HIV-1 In Five Ugandan Mother–Infant Pairs
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences