Temporal, spatial and household dynamics of Typhoid fever in Kasese district, Uganda

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dc.contributor.authorBasuta Mirembe, Bernadette
dc.contributor.authorMazeri, Stella
dc.contributor.authorCallaby, Rebecca
dc.contributor.authorNyakarahuka, Luke
dc.contributor.authorKankya, Clovice
dc.contributor.authorMuwonge, Adrian
dc.date.accessioned2022-08-18T20:20:37Z
dc.date.available2022-08-18T20:20:37Z
dc.date.issued2019
dc.description.abstractTyphoid fever affects 21 million people globally, 1% of whom succumb to the disease. The social, economic and public health consequences of this disease disproportionately affect people in Africa and Asia. In order to design context specific prevention strategies, we need to holistically characterise outbreaks in these settings. In this study, we used retrospective data (2013–2016) at national and district level to characterise temporal and spatial dynamics of Typhoid fever outbreaks using time series and spatial analysis. We then selected cases matched with controls to investigate household socio-economic drivers using a conditional logistic regression model, and also developed a Typhoid fever outbreak-forecasting framework. The incidence rate of Typhoid fever at national and district level was ~ 160 and 60 cases per 100,000 persons per year, respectively, predominantly in urban areas. In Kasese district, Bwera sub-county registered the highest incidence rate, followed by Kisinga, Kitholhu and Nyakiyumbu sub-counties. The male-female case ratio at district level was at 1.68 and outbreaks occurred between the 20th and 40th week (May and October) each year following by seven weeks of precipitation. Our forecasting framework predicted outbreaks better at the district level rather than national. We identified a temporal window associated with Typhoid fever outbreaks in Kasese district, which is preceded by precipitation, flooding and displacement of people. We also observed that areas with high incidence of Typhoid fever also had high environmental contamination with limited water treatment. Taken together with the forecasting framework, this knowledge can inform the development of specific control and preparedness strategies at district and national level.en_US
dc.identifier.citationMirembe BB, Mazeri S, Callaby R, Nyakarahuka L, Kankya C, Muwonge A (2019) Temporal, spatial and household dynamics of Typhoid fever in Kasese district, Uganda. PLoS ONE 14(4): e0214650. https://doi.org/10.1371/ journal.pone.0214650en_US
dc.identifier.urihttps://doi.org/10.1371/ journal.pone.0214650
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4309
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectSpatialen_US
dc.subjectHousehold dynamicsen_US
dc.subjectTyphoid feveren_US
dc.subjectKasese districten_US
dc.subjectUgandaen_US
dc.titleTemporal, spatial and household dynamics of Typhoid fever in Kasese district, Ugandaen_US
dc.typeArticleen_US
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