Effect of single-dose anthelmintic treatment during pregnancy on an infant’s response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled tria

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dc.contributor.authorWebb, Emily L.
dc.contributor.authorMawa, Patrice A
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorKizito, Dennison
dc.contributor.authorNanteza, Bridget
dc.contributor.authorNampijja, Margaret
dc.contributor.authorMuhangi, Lawrence
dc.date.accessioned2023-03-07T16:43:08Z
dc.date.available2023-03-07T16:43:08Z
dc.date.issued2011
dc.description.abstractHelminth infections affect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth infections affects development of an infant's immune response to immunisations and unrelated infections. In this randomised, double-blind, placebo-controlled trial, we enrolled 2507 women in the second or third trimester of pregnancy who were planning to deliver in Entebbe General Hospital, Entebbe, Uganda. With a computer-generated random number sequence in blocks of 100, we assigned patients to 440 mg albendazole and 40 mg/kg praziquantel (n=628), 440 mg albendazole and a praziquantel-matching placebo (n=625), 40 mg/kg praziquantel and an albendazole-matching placebo (n=626), or an albendazole-matching placebo and praziquantel-matching placebo (n=628). All participants and hospital staff were masked to allocation. Primary outcomes were immune response at age 1 year to BCG, tetanus, and measles immunisation; incidence of infectious diseases during infancy; and vertical HIV transmission. Analysis was by intention-to-treat. This trial is registered, number ISRCTN32849447.en_US
dc.identifier.citationWebb, E. L., Mawa, P. A., Ndibazza, J., Kizito, D., Namatovu, A., Kyosiimire-Lugemwa, J., ... & Elliott, A. M. (2011). Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial. The Lancet, 377(9759), 52-62.https://doi.org/10.1016/S0140-6736(10)61457-2en_US
dc.identifier.issn0140-6736
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8127
dc.language.isoenen_US
dc.publisherThe Lanceten_US
dc.subjectPlacebo-controlled trialen_US
dc.subjectImmunisationen_US
dc.subjectInfectious diseasesen_US
dc.titleEffect of single-dose anthelmintic treatment during pregnancy on an infant’s response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled triaen_US
dc.typeArticleen_US
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