Antinociceptive and anti-inflammatory activities of the aqueous leaf extract of Erlangea tomentosa (Asteraceae) in rats and mice
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Pharmacy & Bioresources
Abstract
Erlangea tomentosa (Asteraceae) is used traditionally in the preparation of herbal remedies for management of several
diseases including pain and inflammation. However, its efficacy and safety have not been scientifically validated. The
aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the aqueous leaf extract of
this plant and its acute toxicity profile in animal models. Antinociceptive activity and anti-inflammatory activity were
determined using the acetic acid-induced writhing model in mice and carrageenan induced inflammation model in rats
respectively. The oral median lethal dose (LD50) was determined using the Lorke’s Method. The extract inhibited pain
due to acetic acid significantly (p<0.05) at doses of 250 mg/kg and 500 mg/kg. The inflammation due to carrageenan
was also significantly (p<0.05) reduced at dose of 500 mg/kg body weight but not 250 mg/Kg. The LD50 value of the
extract was greater than 5,000 mg/kg implying that the extract was safe in 24 hours when administered in a single
high oral dose. Preliminary phytochemical screening revealed the presence of alkaloids, anthraquinones, coumarins,
saponins, tannins and resins. The present study has demonstrated the antinociceptive and anti-inflammatory potential
of aqueous leaf extract of Erlangea tomentosa in rats and mice; thus validates the folkloric use of the plant.
Description
Keywords
Erlangea tomentosa, Antinociception, Anti-inflammation, Acetic acid, Carrageenan
Citation
Muhwana, I., Obakiro, S. B., Ibanda, I., Crucifix, P. G., Afodun, A. M., & Odoma, S. (2020). Antinociceptive and anti-inflammatory activities of the aqueous leaf extract of Erlangea tomentosa (Asteraceae) in rats and mice. Journal of Pharmacy & Bioresources, 17(1), 19-23. https://doi.org/10.4314/jpb.v17i1.4