Mycobacterium tuberculosis Bacteremia in a Cohort of HIV-Infected Patients Hospitalized with Severe Sepsis in Uganda–High Frequency, Low Clinical Sand Derivation of a Clinical Prediction Score

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dc.contributor.authorJacob, Shevin T.
dc.contributor.authorPavlinac, Patricia B.
dc.contributor.authorNakiyingi, Lydia
dc.contributor.authorBanura, Patrick
dc.contributor.authorBaeten, Jared M.
dc.contributor.authorMorgan, Karen
dc.contributor.authorMagaret, Amalia
dc.contributor.authorManabe, Yuka
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorLiles, W. Conrad
dc.contributor.authorWald, Anna
dc.contributor.authorJoloba, Moses L.
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorMichael Scheld, W.
dc.date.accessioned2022-05-25T09:25:26Z
dc.date.available2022-05-25T09:25:26Z
dc.date.issued2013
dc.description.abstractWhen manifested as Mycobacterium tuberculosis (MTB) bacteremia, disseminated MTB infection clinically mimics other serious blood stream infections often hindering early diagnosis and initiation of potentially life-saving anti-tuberculosis therapy. In a cohort of hospitalized HIV-infected Ugandan patients with severe sepsis, we report the frequency, management and outcomes of patients with MTB bacteremia and propose a risk score based on clinical predictors of MTB bacteremia.We prospectively enrolled adult patients with severe sepsis at two Ugandan hospitals and obtained blood cultures for MTB identification. Multivariable logistic regression modeling was used to determine predictors of MTB bacteremia and to inform the stratification of patients into MTB bacteremia risk categories based on relevant patient characteristics.Among 368 HIV-infected patients with a syndrome of severe sepsis, eighty-six (23%) had MTB bacteremia. Patients with MTB bacteremia had a significantly lower median CD4 count (17 vs 64 lymphocytes/mm3, p<0.001) and a higher 30-day mortality (53% vs 32%, p = 0.001) than patients without MTB bacteremia. A minority of patients with MTB bacteremia underwent standard MTB diagnostic testing (24%) or received empiric anti-tuberculosis therapy (15%). Independent factors associated with MTB bacteremia included male sex, increased heart rate, low CD4 count, absence of highly active anti-retroviral therapy, chief complaint of fever, low serum sodium and low hemoglobin. A risk score derived from a model containing these independent predictors had good predictive accuracy [area under the curve = 0.85, 95% CI 0.80–0.89].Nearly 1 in 4 adult HIV-infected patients hospitalized with severe sepsis in 2 Ugandan hospitals had MTB bacteremia. Among patients in whom MTB was suspected, standard tests for diagnosing pulmonary MTB were inaccurate for correctly classifying patients with or without bloodstream MTB infection. A MTB bacteremia risk score can improve early diagnosis of MTB bacteremia particularly in settings with increased HIV and MTB co-infection.en_US
dc.identifier.citationJacob, S. T., Pavlinac, P. B., Nakiyingi, L., Banura, P., Baeten, J. M., Morgan, K., ... & Scheld, W. M. (2013). Mycobacterium tuberculosis bacteremia in a cohort of HIV-infected patients hospitalized with severe sepsis in Uganda–high frequency, low clinical sand derivation of a clinical prediction score. PloS one, 8(8), e70305.https://doi.org/10.1371/journal.pone.0070305en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3306
dc.language.isoenen_US
dc.publisherPloS oneen_US
dc.titleMycobacterium tuberculosis Bacteremia in a Cohort of HIV-Infected Patients Hospitalized with Severe Sepsis in Uganda–High Frequency, Low Clinical Sand Derivation of a Clinical Prediction Scoreen_US
dc.typeArticleen_US
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