Infection with HIV-1 subtype D among Acutely Infected Ugandans is Associated with Higher Median Concentration of Cytokines Compared to Subtype

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dc.contributor.authorKapaata, Anne
dc.contributor.authorBalinda, Sheila N.
dc.contributor.authorKikaire, Bernard
dc.contributor.authorEgesa, Moses
dc.contributor.authorLubyayi, Lawrence
dc.contributor.authorMacharia, Gladys N.
dc.contributor.authorKamali, Anatoli
dc.contributor.authorGilmour, Jill
dc.contributor.authorBagaya, Bernard
dc.contributor.authorSalazar-Gonzalez, Jesus F.
dc.contributor.authorKaleebu, Pontiano
dc.date.accessioned2023-06-22T18:02:36Z
dc.date.available2023-06-22T18:02:36Z
dc.date.issued2022
dc.description.abstractThe observation that HIV-1 subtype D progresses faster to disease than subtype A prompted us to examine cytokine levels early after infection within the predominant viral subtypes that circulate in Uganda and address the following research questions: (1) Do cytokine levels vary between subtypes A1 and D? (2) Do cytokine profiles correlate with disease outcomes? To address these questions, HIV-1 subtypes were determined by population sequencing of the HIV-1 pol gene and 37 plasma cytokine concentrations were evaluated using V-Plex kits on Meso Scale Discovery platform in 65 recent sero-converters. HIV-1 subtype D (pol) infections exhibited significantly higher median plasma concentrations of IL-5, IL-16, IL-1α, IL-7, IL-17A, CCL11 (Eotaxin-1), CXCL10 (IP-10), CCL13 (MCP-4) and VEGF-D compared to subtype A1 (pol) infections. We also found that IL-12/23p40 and IL-1α were associated with faster CD4+T cell count decline, while bFGF was associated with maintenance of CD4+ counts above 350 cells/microliter. Our results suggest that increased production of cytokines in early HIV infection may trigger a disruption of the immune environment and contribute to pathogenic mechanisms underlying the accelerated disease progression seen in individuals infected with HIV-1 subtype D in Uganda.en_US
dc.identifier.citationKapaata, A., Balinda, S. N., Hare, J., Leonova, O., Kikaire, B., Egesa, M., ... & Kaleebu, P. (2022). Infection with HIV-1 subtype D among acutely infected Ugandans is associated with higher median concentration of cytokines compared to subtype A. IJID Regions, 3, 89-95.https://doi.org/10.1016/j.ijregi.2022.03.007en_US
dc.identifier.issn2772-7076
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8969
dc.language.isoenen_US
dc.publisherIJID Regionsen_US
dc.subjectDisease progressionen_US
dc.subjectHIV-1 subtypesen_US
dc.subjectCytokinesen_US
dc.titleInfection with HIV-1 subtype D among Acutely Infected Ugandans is Associated with Higher Median Concentration of Cytokines Compared to Subtypeen_US
dc.typeArticleen_US
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