Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients With BRCA1 or BRCA2 Mutations and Recurrent Ovarian Cancer

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dc.contributor.authorKaye, Stan B.
dc.contributor.authorLubinski, Jan
dc.contributor.authorGourley, Charlie
dc.contributor.authorLowe, Elizabeth S.
dc.contributor.authorKaufman, Bella
dc.date.accessioned2025-01-13T11:04:14Z
dc.date.available2025-01-13T11:04:14Z
dc.date.issued2011-12-27
dc.description.abstractOlaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or BRCA2-deficient cells, has shown promising clinical efficacy in nonrandomized phase II trials in patients with ovarian cancer with BRCA1 or BRCA2 deficiency. We assessed the comparative efficacy and safety of olaparib and pegylated liposomal doxorubicin (PLD) in this patient population.
dc.identifier.citationKaye, S. B., Lubinski, J., Matulonis, U., Ang, J. E., Gourley, C., Karlan, B. Y., ... & Kaufman, B. (2012). Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. Journal of clinical oncology, 30(4), 372-379.
dc.identifier.otherhttps://doi.org/10.1200/JCO.2011.36.9215
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9755
dc.language.isoen
dc.publisherJournal of clinical oncology
dc.titlePhase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients With BRCA1 or BRCA2 Mutations and Recurrent Ovarian Cancer
dc.typeArticle
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