Plasma n-6 Fatty Acid Levels Are Associated With CD4 Cell Counts, Hospitalization, and Mortality in HIV-Infected Patients

Simple item page
dc.contributor.authorKabagambe, Edmond K.
dc.contributor.authorEzeamama, Amara E.
dc.contributor.authorGuwatudde, David
dc.contributor.authorCampos, Hannia
dc.contributor.authorFawzi, Wafaie W.
dc.date.accessioned2022-04-29T21:03:48Z
dc.date.available2022-04-29T21:03:48Z
dc.date.issued2016
dc.description.abstractFatty acids, including n-6 series, modulate immune function, but their effect on CD4 cell counts, death, or hospitalization in HIV-infected patients on antiretroviral therapy is unknown. Methods: In a randomized trial for effects of multivitamins in HIVinfected patients in Uganda, we used gas chromatography to measure plasma n-6 fatty acids at baseline; determined CD4 counts at baseline, 3, 6, 12, and 18 months; and recorded hospitalization or death events. The associations of fatty acids with CD4 counts and events were analyzed using repeated-measures analysis of variance and Cox regression, respectively. Results: Among 297 patients with fatty acids measurements, 16 patients died and 69 were hospitalized within 18 months. Except for linoleic acid, n-6 fatty acids levels were positively associated with CD4 counts at baseline but not during follow-up. In models that included all 5 major n-6 fatty acids, age; sex; body mass index; anemia status; use of antiretroviral therapy, multivitamin supplements, and alcohol; and the risk of death or hospitalization decreased significantly with an increase in linoleic acid and gamma-linolenic acid levels, whereas associations for dihomo-gamma-linolenic acid, arachidonic acid, and aolrenic acid were null. The hazard ratios (95% confidence intervals) per 1 SD increase in linoleic acid and gammalinolenic acid were 0.73 (0.56–0.94) and 0.51 (0.36–0.72), respectively. Gamma-linolenic acid remained significant (hazard ratio = 0.51; 95% confidence interval: 0.35 to 0.68) after further adjustment for other plasma fatty acids. Conclusions: Lower levels of gamma-linolenic acid are associated with lower CD4 counts and an increased risk of death or hospitalization. These results suggest a potential for using n-6 fatty acids to improve outcomes from antiretroviral therapy.en_US
dc.identifier.citationKabagambe, E. K., Ezeamama, A. E., Guwatudde, D., Campos, H., & Fawzi, W. (2016). Plasma n6-fatty acid levels are associated with CD4 cell counts, hospitalization and mortality in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999), 73(5), 598.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/pmc5110389/
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3017
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectFatty acidsen_US
dc.subjectn-6 fatty acidsen_US
dc.subjectMortalityen_US
dc.subjectHospitalizationen_US
dc.subjectHIVen_US
dc.titlePlasma n-6 Fatty Acid Levels Are Associated With CD4 Cell Counts, Hospitalization, and Mortality in HIV-Infected Patientsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Plasma n-6 Fatty Acid Levels Are Associated With CD4.pdf
Size:
138.4 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences