Frequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB

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dc.contributor.authorAnguzu, Godwin
dc.contributor.authorGupta, Amanda J.
dc.contributor.authorOchom, Emmanuel
dc.contributor.authorTseng, Ashley S.
dc.contributor.authorZhang, Meixin
dc.contributor.authorBarnabas, Ruanne V.
dc.contributor.authorFlaxman, Abraham D.
dc.contributor.authorKatamba, Achilles
dc.contributor.authorDavis, J. Lucian
dc.contributor.authorRoss, Jennifer M.
dc.date.accessioned2023-01-18T16:49:09Z
dc.date.available2023-01-18T16:49:09Z
dc.date.issued2022
dc.description.abstractStrong epidemiological links between HIV and tuberculosis (TB) may make household TB contact investigation an efficient strategy for HIV screening and finding individuals in serodifferent partnerships at risk of HIV and linking them to HIV prevention services. We aimed to compare the proportions of HIV serodifferent couples in TB-affected households and in the general population of Kampala, Uganda. Methods: We included data from a cross-sectional trial of HIV counselling and testing (HCT) in the context of home-based TB evaluation in Kampala, Uganda in 2016-2017. After obtaining consent, community health workers visited the homes of participants with TB to screen contacts for TB and offer HCT to household members ≥15 years. We defined index participants and their spouses and parents of the same index participant as couples, and classified couples as serodifferent if confirmed by self-reported HIV status or by HIV testing results. We used a two-sample test of proportions to compare the frequency of HIV serodifference among couples in the study to its prevalence among couples in Kampala in the 2011 Uganda AIDS Indicator Survey (UAIS). Results: We included 323 index TB participants and 507 household contacts aged ≥18. Most index participants (55%) were male, while most (68%) adult contacts were female. There was ≥1 couple in 115/323 (35.6%) households, with most couples (98/115, 85.2%) including the index participant and spouse. The proportion of households with HIV-serodifferent couples was 18/323 (5.6%), giving a number-needed-to-screen of 18 households. The proportion of HIV serodifference among couples identified in the trial was significantly higher than among couples in the UAIS (15.7% vs 8%, p=0.039). The 18 serodifferent couples included 14 (77.8%) where the index participant was living with HIV and the spouse was HIV-negative, and 4 (22.2%) where the index partner was HIV-negative, while the spouse was living with HIV. Conclusions: The frequency of HIV serodifference among couples identified in TB-affected households was higher than in the general population. TB household contact investigation may be an efficient strategy for identifying people with substantial exposure to HIV and linking them to HIV prevention services.en_US
dc.identifier.citationAnguzu, G., Gupta, A. J., Ochom, E., Tseng, A. S., Zhang, M., Barnabas, R. V., ... & Ross, J. M. (2022). Frequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB. medRxiv.en_US
dc.identifier.urihttps://www.medrxiv.org/content/10.1101/2022.11.28.22282837.abstract
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7038
dc.language.isoenen_US
dc.publishermedRxiven_US
dc.subjectHIV preventionen_US
dc.subjectSerodifferenten_US
dc.subjectPrEPen_US
dc.subjectHousehold contacten_US
dc.subjectTuberculosisen_US
dc.titleFrequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TBen_US
dc.typeArticleen_US
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