Antibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomised clinical trial evaluating the effect of administration time on the incidence of postoperative infections

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dc.contributor.authorDlamini, Lomangisi D.
dc.contributor.authorSekikubo, Musa
dc.contributor.authorTumukunde, Janat
dc.contributor.authorKojjo, Charles
dc.contributor.authorOcen, Davidson
dc.contributor.authorWabule, Agnes
dc.contributor.authorKwizera, Arthur
dc.date.accessioned2022-05-27T14:44:37Z
dc.date.available2022-05-27T14:44:37Z
dc.date.issued2015
dc.description.abstractProphylactic antibiotics are used to prevent postoperative infections after caesarean section. Studies have suggested that the timing of prophylaxis plays an important role. Over the years, the role of the anaesthesiologist in the administration of prophylactic antibiotics has become prominent. Therefore, there is an increasing need for anaesthesia providers to understand the rationale of antibiotic prophylaxis. We therefore sought to compare the effect of antibiotics prophylaxis within 1 hour before skin incision and after skin incision on the incidence of postoperative infections in patients undergoing caesarean section at Mulago Hospital. Methods: We conducted a single-blind randomised clinical trial conducted at Mulago Hospital evaluating 464 patients undergoing emergency caesarean section. Patients were randomly assigned a group number that allocated them to either arm of the study. They received the same prophylactic antibiotic according to their allotment, that is, either within 1 hour before skin incision or after skin incision as per current standards of practice in Mulago Hospital. They were followed up to detect infection up to 10 days postoperatively. The primary outcome was postoperative infection. The data collected were analysed with STATA version 12 using univariate and bivariate analysis. Results: The risk of overall postoperative infection was significantly lower when prophylaxis was given within an hour before incision (RR O.77, 95% CI 0.62–0.97). We also found endometritis to be significantly reduced in the pre-incision group (RR 0.62; 95% CI 0.39–0.99; P value 0.036). Conclusions: Giving prophylactic antibiotics before skin incision reduces risk of postoperative infection, in particular of endometritis.en_US
dc.identifier.citationDlamini, L. D., Sekikubo, M., Tumukunde, J., Kojjo, C., Ocen, D., Wabule, A., & Kwizera, A. (2015). Antibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomised clinical trial evaluating the effect of administration time on the incidence of postoperative infections. BMC pregnancy and childbirth, 15(1), 1-7.DOI 10.1186/s12884-015-0514-3en_US
dc.identifier.otherDOI 10.1186/s12884-015-0514-3
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3583
dc.language.isoenen_US
dc.publisherBMC pregnancy and childbirthen_US
dc.subjectAntibiotic prophylaxisen_US
dc.subjectCaesarean sectionen_US
dc.subjectInfectionen_US
dc.subjectLow-income settingen_US
dc.titleAntibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomised clinical trial evaluating the effect of administration time on the incidence of postoperative infectionsen_US
dc.typeArticleen_US
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