Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

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dc.contributor.authorAmano, Shinya U.
dc.contributor.authorCohen, Jessica L.
dc.contributor.authorVangala, Pranitha
dc.contributor.authorTencerova, Michaela
dc.contributor.authorNicoloro, Sarah M.
dc.contributor.authorYawe, Joseph C.
dc.contributor.authorCzech, Michael P.
dc.contributor.authorAouadi, Myriam
dc.date.accessioned2023-04-13T14:57:51Z
dc.date.available2023-04-13T14:57:51Z
dc.date.issued2014
dc.description.abstractAdipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete cytokines that can promote insulin resistance. AT macrophages (ATMs) are thought to originate from bone-marrow-derived monocytes, which infiltrate the tissue from the circulation. Here, we show that a major fraction of macrophages unexpectedly undergo cell division locally within AT, as detected by Ki67 expression and 5-ethynyl-2′-deoxyuridine incorporation. Macrophages within the visceral AT (VAT), but not those in other tissues (including liver and spleen), displayed increased proliferation in obesity. Importantly, depletion of blood monocytes had no impact on ATM content, whereas their proliferation in situ continued. Treatment with monocyte chemotactic protein 1 (MCP-1) induced macrophage cell division in AT explants, whereas mcp-1 deficiency in vivo decreased ATM proliferation. These results reveal that, in addition to blood monocyte recruitment, in situ proliferation driven by MCP-1 is an important process by which macrophages accumulate in the VAT in obesity.en_US
dc.identifier.citationAmano, S. U., Cohen, J. L., Vangala, P., Tencerova, M., Nicoloro, S. M., Yawe, J. C., ... & Aouadi, M. (2014). Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell metabolism, 19(1), 162-171.https://doi.org/10.1016/j.cmet.2013.11.017en_US
dc.identifier.issn1550-4131
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8451
dc.language.isoenen_US
dc.publisherCell metabolismen_US
dc.subjectObesity-Associated Adipose Tissue Inflammationen_US
dc.subjectLocal Proliferationen_US
dc.subjectMacrophagesen_US
dc.titleLocal Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammationen_US
dc.typeArticleen_US
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