Management of Filamentous Fungal Keratitis: A Pragmatic Approach

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dc.contributor.authorHoffman, Jeremy J.
dc.contributor.authorArunga, Simon
dc.contributor.authorMohamed Ahmed, Abeer H. A.
dc.contributor.authorHu, Victor H.
dc.contributor.authorBurton, Matthew J.
dc.date.accessioned2023-03-24T16:57:14Z
dc.date.available2023-03-24T16:57:14Z
dc.date.issued2022
dc.description.abstractFilamentous fungal infections of the cornea known as filamentous fungal keratitis (FK) are challenging to treat. Topical natamycin 5% is usually first-line treatment following the results of several landmark clinical trials. However, even when treated intensively, infections may progress to corneal perforation. Current topical antifungals are not always effective and are often unavailable. Alternatives topical therapies to natamycin include voriconazole, chlorhexidine, amphotericin B and econazole. Surgical therapy, typically in the form of therapeutic penetrating keratoplasty, may be required for severe cases or following corneal perforation. Alternative treatment strategies such as intrastromal or intracameral injections of antifungals may be used. However, there is often no clear treatment strategy and the evidence to guide therapy is often lacking. This review describes the different treatment options and their evidence and provides a pragmatic approach to the management of fungal keratitis, particularly for clinicians working in tropical, low-resource settings where fungal keratitis is most prevalent.en_US
dc.identifier.citationHoffman, J.J.; Arunga, S.; Mohamed Ahmed, A.H.A.; Hu, V.H.; Burton, M.J. Management of Filamentous Fungal Keratitis: A Pragmatic Approach. J. Fungi 2022, 8, 1067. https://doi.org/10.3390/ jof8101067en_US
dc.identifier.urihttps://doi.org/10.3390/ jof8101067
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8288
dc.language.isoenen_US
dc.publisherJournal of Fungien_US
dc.subjectMicrobial keratitisen_US
dc.subjectFungal keratitisen_US
dc.subjectManagementen_US
dc.subjectAntifungalsen_US
dc.subjectMicrobiologyen_US
dc.subjectNatamycinen_US
dc.subjectChlorhexidineen_US
dc.titleManagement of Filamentous Fungal Keratitis: A Pragmatic Approachen_US
dc.typeArticleen_US
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