Detection of Kaposi Sarcoma–Associated Herpesvirus DNA in Saliva and Buffy-Coat Samples from Children with Sickle Cell Disease in Uganda

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dc.contributor.authorMbulaiteye, Sam M.
dc.contributor.authorPfeiffer, Ruth M.
dc.contributor.authorEngels, Eric A.
dc.contributor.authorMarshall, Vickie
dc.contributor.authorBakaki, Paul M.
dc.contributor.authorOwor, Anchilla M.
dc.contributor.authorNdugwa, Christopher M.
dc.contributor.authorMbidde, Edward Katongole
dc.contributor.authorGoedert, James J.
dc.contributor.authorBiggar, Robert J.
dc.contributor.authorWhitby, Denise
dc.date.accessioned2022-01-24T16:28:29Z
dc.date.available2022-01-24T16:28:29Z
dc.date.issued2004
dc.description.abstractAmong 233 children, Kaposi sarcoma–associated herpesvirus (KSHV) DNA was detected in 43% of children seropositive for both K8.1 and orf73, in 29% of children seropositive for K8.1 only, in 14% of children seropositive for orf73 only, and in 7% of children seronegative for both K8.1 and orf73; among 228 mothers, KSHV DNA was detected in 27%, 25%, 4%, and 1%, respectively. KSHV DNA was detected more frequently and at higher levels in saliva than in buffy-coat samples and in children than in mothers. In both children and mothers, detection in saliva was associated with detection in peripheral blood. Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva.en_US
dc.identifier.citationMbulaiteye, S. M., Pfeiffer, R. M., Engels, E. A., Marshall, V., Bakaki, P. M., Owor, A. M., ... & Whitby, D. (2004). Detection of Kaposi Sarcoma—Associated Herpesvirus DNA in Saliva and Buffy-Coat Samples from Children with Sickle Cell Disease in Uganda. The Journal of infectious diseases, 190(8), 1382-1386.en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1509
dc.language.isoenen_US
dc.publisherThe Journal of infectious diseasesen_US
dc.titleDetection of Kaposi Sarcoma–Associated Herpesvirus DNA in Saliva and Buffy-Coat Samples from Children with Sickle Cell Disease in Ugandaen_US
dc.typeArticleen_US
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