The Bacterial and Viral Complexity of Postinfectious Hydrocephalus in Uganda

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dc.contributor.authorPaulson, Joseph N.
dc.contributor.authorWilliams, Brent L.
dc.contributor.authorHehnly, Christine
dc.contributor.authorMishra, Nischay
dc.contributor.authorSinnar, Shamim A.
dc.contributor.authorZhang, Lijun
dc.contributor.authorSsentongo, Paddy
dc.contributor.authorKabachelor, Edith Mbabazi
dc.contributor.authorWijetunge, Dona S. S.
dc.contributor.authorBredow, Benjamin von
dc.contributor.authorMulondo, Ronnie
dc.contributor.authorKiwanuka, Julius
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorBazira, Joel
dc.contributor.authorBebell, Lisa M.
dc.contributor.authorBurgoine, Kathy
dc.contributor.authorCouto-Rodriguez, Mara
dc.contributor.authorEricson, Jessica E.
dc.contributor.authorErickson, Tim
dc.contributor.authorFerrari, Matthew
dc.contributor.authorGladstone, Melissa
dc.contributor.authorGuo, Cheng
dc.contributor.authorHaran, Murali
dc.contributor.authorHornig, Mady
dc.contributor.authorIsaacs, Albert M.
dc.contributor.authorKaaya, Brian Nsubuga
dc.contributor.authorKangere, Sheila M.
dc.contributor.authorKulkarni, Abhaya V.
dc.contributor.authorKumbakumba, Elias
dc.contributor.authorLi, Xiaoxiao
dc.contributor.authorLimbrick, David D.
dc.contributor.authorMagombe, Joshua
dc.contributor.authorMorton, Sarah U.
dc.contributor.authorMugamba, John
dc.contributor.authorNg, James
dc.contributor.authorOlupot, Peter Olupot
dc.contributor.authorOnen, Justin
dc.contributor.authorPeterson, Mallory R.
dc.contributor.authorRoy, Farrah
dc.contributor.authorSheldon, Kathryn
dc.contributor.authorTownsend, Reid
dc.contributor.authorWeeks, Andrew D.
dc.contributor.authorWhalen, Andrew J.
dc.contributor.authorQuackenbush, John
dc.contributor.authorSsenyonga, Peter
dc.contributor.authorGalperin, Michael Y.
dc.contributor.authorAlmeida, Mathieu
dc.contributor.authorAtkins, Hannah
dc.contributor.authorWarf, Benjamin C.
dc.contributor.authorLipkin, W. Ian
dc.contributor.authorBroach, James R.
dc.contributor.authorSchiff, Steven J.
dc.date.accessioned2022-01-23T14:04:45Z
dc.date.available2022-01-23T14:04:45Z
dc.date.issued2020
dc.description.abstractPostinfectious hydrocephalus (PIH), often following neonatal sepsis, is the most common cause of pediatric hydrocephalus world-wide, yet the microbial pathogens remain uncharacterized. Characterization of the microbial agents causing PIH would lead to an emphasis shift from surgical palliation of cerebrospinal fluid (CSF) accumulation to prevention. We examined blood and CSF from 100 consecutive cases of PIH and control cases of non-postinfectious hydrocephalus (NPIH) in infants in Uganda. Genomic testing was undertaken for bacterial, fungal, and parasitic DNA, DNA and RNA sequencing for viral identification, and extensive bacterial culture recovery. We uncovered a major contribution to PIH from Paenibacillus, upon a background of frequent cytomegalovirus (CMV) infection. CMV was only found in CSF in PIH cases. A facultatively anaerobic isolate was recovered. Assembly of the genome revealed a strain of P. thiaminolyticus. In mice, this isolate designated strain Mbale, was lethal in contrast with the benign reference strain. These findings point to the value of an unbiased pan-microbial approach to characterize PIH in settings where the organisms remain unknown, and enables a pathway towards more optimal treatment and prevention of the proximate neonatal infections.en_US
dc.identifier.citationPaulson, J. N., Williams, B. L., Hehnly, C., Mishra, N., Sinnar, S. A., Zhang, L., ... & Schiff, S. J. (2020). The Bacterial and Viral Complexity of Postinfectious Hydrocephalus in Uganda. Science translational medicine, 12(563).doi: 10.1126/scitranslmed.aba0565en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1469
dc.language.isoenen_US
dc.publisherScience translational medicineen_US
dc.titleThe Bacterial and Viral Complexity of Postinfectious Hydrocephalus in Ugandaen_US
dc.typeArticleen_US
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