Occurrence Of Anti-D Alloantibodies Among Pregnant Women In Kasese District, Western Uganda

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dc.contributor.authorMbalibulha, Yona
dc.contributor.authorMuwanguzi, Enoch
dc.contributor.authorMugyenyi, Godfrey R.
dc.contributor.authorNatukunda, Bernard
dc.date.accessioned2022-01-24T16:08:55Z
dc.date.available2022-01-24T16:08:55Z
dc.date.issued2015
dc.description.abstractThis study was undertaken to determine the distribution of ABO/RhD (rhesus D antigen) blood phenotypes, prevalence of anti-D alloantibodies, and the risk factors for alloimmunization among pregnant women in Kasese District, Western Uganda. Ethylenediamine tetraacetic acid-containing plasma samples and serum samples were taken from pregnant women attending the antenatal clinic. The blood groups were identified using the microplate grouping method, while the presence of anti-D alloantibodies was detected by the indirect antiglobulin test (IAT). Data were also collected from the pregnant women on the risk factors associated with anti-D alloantibody formation.Among the 726 participants, the blood group distribution was as follows: O: 356 (49.%); A: 190 (26.%); B: 152 (21%); and AB: 28 (4%). A total of 28 (3.86%) pregnant women were RhD negative. Anti-D alloantibodies were detected in 88 (12.1%) of the participants; and of these, 13 (14.8%) were RhD negative. Statistically significant risk factors for anti-D alloimmunization included miscarriage, stillbirth, and postpartum hemorrhage.Blood group O was the most common among the pregnant women in this study and the prevalence of Rh negativity was 3.8%. The frequency of anti-D alloimmunization among pregnant women in Kasese District was 12.12%, with 85.5% of these being RhD positive. Risk factors such as a history of stillbirths, miscarriages, and incidence of postpartum hemorrhage were significantly associated with anti-D alloimmunization. There is a need to routinely carry out antenatal blood grouping and IAT screening on pregnant women in Uganda to detect anti-D alloimmunization. Given the high prevalence of anti-D alloantibody formation among RhD-positive women, we recommend additional research studies on the role of autoimmunity among antigen-positive women, as well as the occurrence of RhD variants plus their implications on hemolytic disease of the fetus and newborn, in Uganda.en_US
dc.identifier.citationMbalibulha, Y., Muwanguzi, E., Mugyenyi, G. R., & Natukunda, B. (2015). Occurrence of anti-D alloantibodies among pregnant women in Kasese District, Western Uganda. Journal of blood medicine, 6, 125.en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1507
dc.language.isoenen_US
dc.publisherJournal of blood medicineen_US
dc.subjectABO/RhD, blood groups, anti-D alloimmunization, indirect antiglobulin test, pregnant women, Western Ugandaen_US
dc.titleOccurrence Of Anti-D Alloantibodies Among Pregnant Women In Kasese District, Western Ugandaen_US
dc.typeArticleen_US
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